{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:38:03Z","timestamp":1777941483736,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,12]],"date-time":"2013-05-12T00:00:00Z","timestamp":1368316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Isolated optic neuritis (<jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>) is frequently the initial symptom of multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). The aim of our study was to investigate the risk of conversion to <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> in children following isolated <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> and to evaluate the performance of current diagnostic methods such as cranial magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">cMRI<\/jats:styled-content>), visual evoked potentials (<jats:styled-content style=\"fixed-case\">VEP<\/jats:styled-content>s) and oligoclonal bands in spinal fluid (<jats:styled-content style=\"fixed-case\">OCB<\/jats:styled-content>) as predictive factors for <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 159 patients presenting with acute ON between 2000 and 2010 at the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epartment of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ediatrics, <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity of <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>rlangen, were screened; 34 patients with isolated ON were identified. <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rogression to <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> was defined according to the revised <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>c<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>onald criteria 2005. <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ge, sex, <jats:styled-content style=\"fixed-case\">VEP<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> type, <jats:styled-content style=\"fixed-case\">cMRI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OCB<\/jats:styled-content> and visual recovery were assessed as predictors of progression to <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> using simple logistic regressions. A multiple logistic regression model included variables found to be significant in univariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal <jats:styled-content style=\"fixed-case\">cMRI<\/jats:styled-content> was associated with an increase in the odds of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> development (odds ratio 20.57; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.16\u2013196.10, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), as was positive <jats:styled-content style=\"fixed-case\">OCB<\/jats:styled-content> (odds ratio 12.0; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.29\u2013111.32, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). However, only <jats:styled-content style=\"fixed-case\">cMRI<\/jats:styled-content> remained statistically significant in multiple regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multiple sclerosis\u2010like <jats:styled-content style=\"fixed-case\">cMRI<\/jats:styled-content> lesions and <jats:styled-content style=\"fixed-case\">OCB<\/jats:styled-content> are suitable for assessing the risk of progression to <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> following isolated <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content>, as children with both <jats:styled-content style=\"fixed-case\">cMRI<\/jats:styled-content> abnormalities and positive <jats:styled-content style=\"fixed-case\">OCB<\/jats:styled-content> at onset of <jats:styled-content style=\"fixed-case\">ON<\/jats:styled-content> are at high risk of developing <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12184","type":"journal-article","created":{"date-parts":[[2013,5,12]],"date-time":"2013-05-12T19:38:43Z","timestamp":1368387523000},"page":"1292-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Predicting multiple sclerosis following isolated optic neuritis in children"],"prefix":"10.1111","volume":"20","author":[{"given":"N.","family":"Heussinger","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Clinic of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kontopantelis","sequence":"additional","affiliation":[{"name":"Institute of Population Health University of Manchester Manchester 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