{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:46:36Z","timestamp":1769125596840,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T00:00:00Z","timestamp":1369353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Detection of paroxysmal atrial fibrillation (p<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) after an ischaemic cerebrovascular event is of imminent interest, because oral anticoagulation as a highly effective secondary preventive treatment is available. Whereas permanent atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF)<\/jats:styled-content> can be detected during routine electrocardiogram (<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>), longer detection duration will detect more p<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> but might be resource consuming. The current study tried to identify clinical predictors for p<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> detected during long\u2010term <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>olter <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> and clinical follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with acute ischaemic stroke were prospectively investigated with an intensified algorithm to detect p<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> (7\u2010day <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>olter <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>, follow\u2010up investigations after 90\u00a0days and 1\u00a0year).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and eighty\u2010one patients were included, 44 of whom had to be excluded since they presented with permanent <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> and another 13 patients had to be excluded due to other causes leaving 224 patients (mean age 68.5\u00a0years, 58.5% male). Twenty\u2010nine (12.9%) patients could be identified to have p<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> during prolonged <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>olter monitoring, an additional 13 (5.8%) after follow\u2010up investigations. Multivariate analysis identified advanced age [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1.05, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.01\u20131.08] as well as clinical symptoms &gt;24\u00a0h (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.73\u201315.48) and a history of coronary artery disease (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.14, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.35\u20137.28) to be predictive for the detection of p<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In acute stroke patients with advanced age, history of coronary artery disease and clinical symptoms &gt;24\u00a0h, a prolonged <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>olter <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> monitoring and follow\u2010up is warranted to identify p<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>. This could increase the detection rate of patients requiring anticoagulation and may be able to reduce the risk of recurrent stroke in the case of successful anticoagulation of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12198","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T11:44:46Z","timestamp":1369395886000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical predictors to identify paroxysmal atrial fibrillation after ischaemic stroke"],"prefix":"10.1111","volume":"21","author":[{"given":"J.","family":"Wohlfahrt","sequence":"first","affiliation":[{"name":"Department of Neurology University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Stahrenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Weber\u2010Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gr\u00f6schel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wasser","sequence":"additional","affiliation":[{"name":"Department of Neurology University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Edelmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen G\u00f6ttingen 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