{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:25:01Z","timestamp":1773908701114,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T00:00:00Z","timestamp":1370563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Intracranial arterial stenosis (<jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>) is one of the most common causes of ischaemic stroke in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia. Knowledge of the prevalence and risk factors of asymptomatic <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> is limited. The prevalence of <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>was therefore investigated and its risk factors in a <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese community\u2010based population were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2010 to 2011, a stratified (by sex and age) random sample of 5440 participants aged 40\u00a0years or older were enrolled in the study. <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> was assessed using <jats:styled-content style=\"fixed-case\">t<\/jats:styled-content>ranscranial <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler. Logistic regression was used to evaluate potential risk factors associated with <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> in participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 13.2% (95% CI 12.3\u201314.1) of the subjects had <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>, and women were more likely than men to have <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> in the 40\u201349 year age group. Hypertension [odds ratio (OR) = 2.23, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.87\u20132.66], diabetes (OR =\u00a01.99, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.62\u20132.45), left ventricular hypertrophy (OR\u00a0=\u00a01.66, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.18\u20132.34) and elevated high\u2010sensitivity C\u2010reactive protein (OR\u00a0=\u00a01.55, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.19\u20132.02) were independently associated with higher prevalence of <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> after adjusting for age, gender, body mass index, smoking status and other covariates. Of the 716 <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> individuals, 90.6% had one or more of these risk factors. Amongst the subjects who had at least one risk factor, 15.2% had <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intracranial artery stenosis is common in the Chinese population. Individuals who had one or more risk factors were more likely to have <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>, suggesting more aggressive risk factor management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12210","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T11:55:36Z","timestamp":1370606136000},"page":"1479-1485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence and risk factors of asymptomatic intracranial arterial stenosis in a community\u2010based population of <scp>C<\/scp>hinese adults"],"prefix":"10.1111","volume":"20","author":[{"given":"S.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology BeijingTianTan Hospital Capital Medical University Beijing China"},{"name":"Department of Neurology The General Hospital of Chinese People's Armed Police Forces Beijing 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