{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:23:31Z","timestamp":1790731411447,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>There is a paucity of data available regarding the occurrence of sleep disorders in myotonic dystrophy type 2 (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2). In this study the sleep\u2013wake cycle and daytime sleepiness were investigated in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients and compared with results from healthy subjects and myotonic dystrophy type 1 (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 outpatients, 12 age\u2010 and sex\u2010matched healthy controls and 18 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1 patients were recruited. Subjective quality of sleep was assessed by means of the Pittsburgh Sleep Quality Index (<jats:styled-content style=\"fixed-case\">PSQI<\/jats:styled-content>). Both the Epworth Sleepiness Scale and the Daytime Sleepiness Scale were performed in order to evaluate excessive daytime sleepiness (<jats:styled-content style=\"fixed-case\">EDS<\/jats:styled-content>). All participants underwent polysomnographic monitoring over 48\u00a0h as well as the Multiple Sleep Latency Test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sleep efficiency was &lt;\u00a090% in 12\/12 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients, and significantly reduced when compared with controls or with <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1. Decreased sleep efficiency was associated with sleep\u2010disordered breathing in seven out of 12 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients and\/or periodic limbs movements of sleep (<jats:styled-content style=\"fixed-case\">PLMS<\/jats:styled-content>) in three out of eight patients. Six <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients showed <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> sleep without atonia, whereas none of the controls or <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1 patients showed <jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content> sleep dysregulation. The global <jats:styled-content style=\"fixed-case\">PSQI<\/jats:styled-content> score was higher in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients than in controls and <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sleep quality in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients is poorer than in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1 patients and controls. Sleep apnea is the most common sleep disorder in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients. Obstructive sleep apnea and sleep fragmentation may represent the main cause of <jats:styled-content style=\"fixed-case\">EDS<\/jats:styled-content>, whereas <jats:styled-content style=\"fixed-case\">PLMS<\/jats:styled-content> is a frequent finding in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12226","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T04:55:53Z","timestamp":1373432153000},"page":"929-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Sleep disorders in myotonic dystrophy type 2: a controlled polysomnographic study and self\u2010reported questionnaires"],"prefix":"10.1111","volume":"21","author":[{"given":"A.","family":"Romigi","sequence":"first","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Placidi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Izzi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Marciani","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurosciences Neuromuscular Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. B.","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"},{"name":"Fondazione Santa Lucia IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Terracciano","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurosciences Neuromuscular Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"},{"name":"Fondazione Santa Lucia IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vitrani","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Neuromuscular and Rare Neurological Diseases Centre Neurology &amp; Neurophysiopathology Unit ASO San Camillo\u2010Forlanini Hospital of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Di Gioia","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurophysiopathology Sleep Medicine Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Neurosciences Neuromuscular Centre University of Rome \u2018Tor Vergata\u2019 Rome Italy"},{"name":"Fondazione Santa Lucia IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03352.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.2.165"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342895"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.2.535"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.192591"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.07.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2006.0511"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_2_6_10_1","first-page":"748","article-title":"The atlas task force.Recording and scoring leg movements","volume":"16","author":"ASDA","year":"1993","journal-title":"Sleep"},{"key":"e_1_2_6_11_1","volume-title":"ICSD\u20102\u2010International Classification of Sleep disorders","author":"American Academy of Sleep Medicine","year":"2005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.8.993"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.158261"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr299"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.12.1938"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2012.08.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.01302001a"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.12.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1126"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.9.757"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.043455"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12226","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:50:54Z","timestamp":1695552654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,10]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/ene.12226"],"URL":"https:\/\/doi.org\/10.1111\/ene.12226","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,10]]},"assertion":[{"value":"2013-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}