{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:17:14Z","timestamp":1777540634930,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Disappointing outcomes from clinical trials involving amyloid\u2010modifying therapies for Alzheimer's disease (AD) have prompted more focus on the concept of early\u2010stage (E) amnestic mild cognitive impairment (E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content>). However, limited evidence suggests that E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> may represent <jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> at a very early stage of AD. Furthermore, the nature of the progression of E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> to late\u2010stage <jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> (L\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content>) remains unclear. Therefore, the aim of the present study was to characterize patterns of cortical thinning in both E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> and L\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cortical thicknesses were measured in 190 patients with <jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> and 147 subjects with normal cognition. In accordance with memory test scores involving delayed recall items, <jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> patients were divided into two subgroups, containing 73 E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> subjects with milder memory impairment [scores between \u22121.5 standard deviation (SD) and \u22121.0 SD compared with age\u2010 and education\u2010matched norms] and 117 L\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> subjects with more severe memory impairment (scores lower than \u22121.5 SD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, the E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> group exhibited cortical thinning in the left medial temporal and insular regions, whereas the L\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> group showed cortical thinning in widespread regions, including the bilateral dorsolateral prefrontal, anterior and medial temporal, and temporo\u2010parietal association cortices, and the precuneus. When the two <jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> groups were directly compared, the L\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> group showed greater cortical thinning in the right superior prefrontal, medial temporal, posterior cingulate and lateral parietal cortices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> might represent an early symptomatic stage of AD. Furthermore, L\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content> might resemble AD more closely than E\u2010<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content>, in terms of the topography of cortical thinning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12251","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T15:22:19Z","timestamp":1377184939000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Comparison of cortical thickness in patients with early\u2010stage versus late\u2010stage amnestic mild cognitive impairment"],"prefix":"10.1111","volume":"21","author":[{"given":"B. S.","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology Sungkyunkwan University School of Medicine Samsung Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Sungkyunkwan University School of Medicine Samsung Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Sungkyunkwan University School of Medicine Samsung Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Sungkyunkwan University School of Medicine Samsung Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurology Inha University School of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology Sungkyunkwan University School of Medicine Samsung Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Neurology Gachon University Gil Medical Center Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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