{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:58:47Z","timestamp":1790416727530,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Studies have suggested that multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) might be linked to an overall reduced cancer rate, but a positive relationship is also found for several types of cancer. This study determines whether <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> is associated with cancer risk in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nsurance <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwan were used to assess this issue. The <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> cohort included 1292 patients, and each patient was randomly frequency\u2010matched with four participants without <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>, based on their age, sex and index year (control cohort). <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazards regression analysis was conducted to estimate the influence of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> on cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significantly higher risk of developing overall cancer was found amongst the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> cohort compared with the control cohort [adjusted hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>)\u00a01.85, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u00a01.26\u20132.74], as well as breast cancer (adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a02.23, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a01.11\u20134.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nationwide population\u2010based cohort study revealed that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwanese patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> have a higher risk of developing overall cancer types and breast cancer in particular.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12267","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T08:54:23Z","timestamp":1379753663000},"page":"238-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Increased breast cancer risk for patients with multiple sclerosis: a nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"21","author":[{"given":"L.\u2010M.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Zuoying Branch of Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010L.","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital Taichung Taiwan"},{"name":"Institute of Public Health College of Public Health China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010J.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Health Risk Management China Medical University Taichung Taiwan"},{"name":"Department of Medical Research China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010A.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology China Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science and School of Medicine College of Medicine China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010C.","family":"Sung","sequence":"additional","affiliation":[{"name":"Institute of Public Health College of Public Health China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010H.","family":"Kao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science and School of Medicine College of Medicine China Medical University Taichung Taiwan"},{"name":"Department of Nuclear Medicine and PET Center China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08220-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720170011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70257-7"},{"key":"e_1_2_7_6_1","first-page":"500","article-title":"Multiple sclerosis in Taiwan","volume":"67","author":"Tsai CP","year":"2004","journal-title":"J Chin Med Assoc"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr333"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25524"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051434"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079947"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.175463"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws148"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.195776"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb04941.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21437"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200101000-00023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1142\/9789814261593_0007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2087"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.116178"},{"key":"e_1_2_7_20_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132008","author":"Howlader N","year":"2011"},{"key":"e_1_2_7_21_1","unstructured":"Cancer Statistics Annual Report. Taiwan Cancer Registry.http:\/\/tcr.cph.ntu.edu.tw\/main.php?Page=N2(accessed 02\/07\/2013)."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1684-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458506ms1297oa"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(76)90214-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520300042016"},{"key":"e_1_2_7_26_1","unstructured":"SEER Stat Fact Sheets: Breast.http:\/\/seer.cancer.gov\/statfacts\/html\/breast.html(accessed 02\/07\/2013)."},{"key":"e_1_2_7_27_1","unstructured":"SEER Stat Fact Sheets: Lung and Bronchus.http:\/\/seer.cancer.gov\/statfacts\/html\/lungb.html(accessed 02\/07\/2013)."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0932"},{"key":"e_1_2_7_29_1","volume-title":"Statistical Methods in Cancer Research, Volume II. The Design and Analysis of Cohort Studies","author":"Breslow NE","year":"1987"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511408991"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-008-0291-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.1.69"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508093679"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014606"},{"key":"e_1_2_7_35_1","first-page":"1","article-title":"Effects of smoking on the acute exacerbations of multiple sclerosis","volume":"29","author":"Courville CB","year":"1964","journal-title":"Bull Los Angel Neuro Soc"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073-13.2.49"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2006.09.002"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-2229-4"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2008.n.055"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12267","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T09:45:48Z","timestamp":1696326348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,19]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/ene.12267"],"URL":"https:\/\/doi.org\/10.1111\/ene.12267","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,19]]},"assertion":[{"value":"2013-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}