{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:26:51Z","timestamp":1791268011331,"version":"4.1.0"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:00:00Z","timestamp":1379721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      To provide a detailed phenotypical description of seronegative patients with generalized myasthenia gravis and antibodies to clustered acetylcholine receptors (\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      hRs) and to assess their frequency amongst a French seronegative generalized myasthenia gravis (\n                      <jats:styled-content style=\"fixed-case\">SNMG<\/jats:styled-content>\n                      ) population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A French\n                      <jats:styled-content style=\"fixed-case\">SNMG<\/jats:styled-content>\n                      database was created and the sera from the 37 patients included in it were analysed by immunofluorescence of cell\u2010based assays using cotransfection of\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      hR subunit genes together with rapsyn to densely cluster the\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      hRs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen per cent (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) of the\n                      <jats:styled-content style=\"fixed-case\">SNMG<\/jats:styled-content>\n                      patients were found to have antibodies to clustered\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      hR. They presented either with early onset\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      and thymic hyperplasia, late onset\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      and thymic involution, or thymoma associated\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      . They responded well to cholinesterase inhibitors and immunosuppressants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Patients with antibodies to clustered\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      hR account for a significant proportion of\n                      <jats:styled-content style=\"fixed-case\">SNMG<\/jats:styled-content>\n                      patients and resemble patients with\n                      <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n                      hR antibodies detected by standard radio\u2010immunoprecipitation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.12270","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T18:07:35Z","timestamp":1381514855000},"page":"130-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Antibodies to clustered acetylcholine receptor: expanding the phenotype"],"prefix":"10.1111","volume":"21","author":[{"given":"P.","family":"Devic","sequence":"first","affiliation":[{"name":"Ecole Normale Sup\u00e9rieure de Lyon Laboratoire de Biologie Mol\u00e9culaire de la Cellule CNRS UMR 5239, Universit\u00e9 Lyon 1 Lyon"},{"name":"Hospices Civils de Lyon Service d'explorations neurologiques Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Petiot","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la croix rousse Hospices Civils de Lyon Service d'explorations neurologiques Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Simonet","sequence":"additional","affiliation":[{"name":"Ecole Normale Sup\u00e9rieure de Lyon Laboratoire de Biologie Mol\u00e9culaire de la Cellule CNRS UMR 5239, Universit\u00e9 Lyon 1 Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Stojkovic","sequence":"additional","affiliation":[{"name":"Institut de Myologie H\u00f4pital de la Piti\u00e9 Salp\u00e9tri\u00e8re Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Delmont","sequence":"additional","affiliation":[{"name":"CHU de Nice Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires et SLA Nice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Franques","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie et des Maladies Neuromusculaires CHU la Timone Marseille"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Magot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie CHU de Nantes Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires Nantes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vial","sequence":"additional","affiliation":[{"name":"H\u00f4pital neurologique Pierre Wertheimer Hospices Civils de Lyon Service d'\u00e9lectroneuromyographie Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires Bron"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lagrange","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie CHU de Grenoble Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires Grenoble"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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