{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:39:29Z","timestamp":1789857569820,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T00:00:00Z","timestamp":1386374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Background and purpose<\/jats:title>Greater occipital nerve blockade (GONB<\/jats:styled-content>) has been shown to be effective in episodic cluster headache. However, its use in chronic cluster headache (CCH<\/jats:styled-content>) is less certain. The study aims to prospectively assess the efficacy and consistency of response to GONB<\/jats:styled-content> in a large series of CCH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>CCH<\/jats:styled-content> patients who had a unilateral GONB<\/jats:styled-content> and were referred to the N<\/jats:styled-content>ational H<\/jats:styled-content>ospital for N<\/jats:styled-content>eurology and N<\/jats:styled-content>eurosurgery were studied prospectively. Headache characteristics were collected using headache diaries. Responders were considered to be patients with a complete or partial response lasting at least 7\u00a0days. In a subgroup of responders the outcomes of serial GONB<\/jats:styled-content> performed at 3\u2010monthly intervals were also analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>Eighty\u2010three CCH<\/jats:styled-content> patients were studied. After the first GONB<\/jats:styled-content>, a positive response was observed in 47 (57%) patients: 35 (42%) were rendered pain free, 12 (15%) had a partial benefit and one patient obtained <50% improvement. The duration of a positive response lasted a median of 21\u00a0days (range 7\u2013504\u00a0days). There was a transient worsening of condition in 6% of patients. The overall rate and average duration of response remained consistent after the second [n<\/jats:italic>\u00a0=\u00a037; 31 responders (84%); median duration 21\u00a0days], third [n<\/jats:italic>\u00a0=\u00a028; 20 responders (71%); median duration 25\u00a0days] and fourth [n<\/jats:italic>\u00a0=\u00a014; 10 responders (71%); median duration 23\u00a0days] injections.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>GONB<\/jats:styled-content> seems to be an efficacious treatment with reproducible effects in CCH<\/jats:styled-content> patients. Performed three monthly, GONB<\/jats:styled-content> may have a useful role in the management of CCH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12321","type":"journal-article","created":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T05:51:59Z","timestamp":1386395519000},"page":"338-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Greater occipital nerve blocks in chronic cluster headache: a prospective open\u2010label study"],"prefix":"10.1111","volume":"21","author":[{"given":"G.","family":"Lambru","sequence":"first","affiliation":[{"name":"Headache Group Institute of Neurology Queen Square London UK"},{"name":"The National Hospital for Neurology and Neurosurgery Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Abu Bakar","sequence":"additional","affiliation":[{"name":"Headache Group Institute of Neurology Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Stahlhut","sequence":"additional","affiliation":[{"name":"The National Hospital for Neurology and Neurosurgery Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"McCulloch","sequence":"additional","affiliation":[{"name":"The National Hospital for Neurology and Neurosurgery Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Headache Group Institute of Neurology Queen Square London UK"},{"name":"The National Hospital for Neurology and Neurosurgery Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Shanahan","sequence":"additional","affiliation":[{"name":"The National Hospital for Neurology and Neurosurgery Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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