{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:48:32Z","timestamp":1791190112579,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Commission within the European Union public health programme"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dementia is more common in older age but a number of people develop symptoms at a younger age and are said to have early onset dementia (<jats:styled-content style=\"fixed-case\">EOD<\/jats:styled-content>). Those with <jats:styled-content style=\"fixed-case\">EOD<\/jats:styled-content> face different challenges to those with onset later in life. It has been difficult to quantify this disease burden. This is a systematic review of papers reporting on the prevalence of <jats:styled-content style=\"fixed-case\">EOD<\/jats:styled-content>. A search of Medline and Embase was performed. This was followed by a hand search of the references of these papers. Eleven suitable studies were included. All of the data was from more economically developed countries. The studies were heterogeneous in their design hindering direct comparison. The majority of the papers looked at all types of dementia although many gave a breakdown of the prevalence of different subgroups. A variety of diagnostic criteria was employed. Figures of 38 to 260 per 100\u00a0000 are quoted by papers looking at various different types of dementia together with an onset of between 30 and 64 or up to 420 per 100\u00a0000 for those aged 55\u201364. Prevalence rises as age approaches 65. Epidemiological data for prevalence rates for EOD are sparse. <jats:styled-content style=\"fixed-case\">EOD<\/jats:styled-content> remains a rare condition with low case numbers. Assimilation and comparison of results from existing studies is difficult due to methodological heterogeneity. Cross\u2010national standardization of methodology should be a priority for future research in this area.<\/jats:p>","DOI":"10.1111\/ene.12325","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T14:25:02Z","timestamp":1389623102000},"page":"563-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Estimating the burden of early onset dementia; systematic review of disease prevalence"],"prefix":"10.1111","volume":"21","author":[{"given":"M. A.","family":"Lambert","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Diabetes Medicine University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bickel","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie der Technischen Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar Munchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Prince","sequence":"additional","affiliation":[{"name":"King's College London Institute of Psychiatry London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Fratiglioni","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Von Strauss","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Frydecka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Wroclaw Medical University Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kiejna","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Wroclaw Medical University Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Georges","sequence":"additional","affiliation":[{"name":"Alzheimer Europe Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. L.","family":"Reynish","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine NHS Fife Kirkcaldy UK"},{"name":"Dementia Services Development Centre University of Stirling Stirling UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.1.78"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317509352335"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211001013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2439"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607861003713224"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S26523"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.9.1206"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1615"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700025411"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.7.1025"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000026206"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6985.970"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg204"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/302553"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.4.626"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.6.773"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.542308"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:29:20Z","timestamp":1695558560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,13]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/ene.12325"],"URL":"https:\/\/doi.org\/10.1111\/ene.12325","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,13]]},"assertion":[{"value":"2013-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}