{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T14:52:11Z","timestamp":1774709531140,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The association between use of azathioprine and risk of non\u2010melanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) in patients with myasthenia was evaluated in a nationwide setting. Treatment of autoimmune myasthenia frequently involves long\u2010term exposure to immunosuppressants, including azathioprine. Use of azathioprine increases the risk of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> in organ recipients and probably also in patients with other autoimmune disorders. No previous study has specifically investigated the risk of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> in myasthenia patients treated with azathioprine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2013control study based on Danish population\u2010based registries. Cases were myasthenia patients with a first time diagnosis of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> during 2004\u20132009. Age\u2010 and sex\u2010matched controls were selected amongst myasthenia patients with no history of cancer using incidence density sampling. Prior use of azathioprine in cases and controls was assessed through prescription records (1995\u20132009). Conditional logistic regression was used to calculate odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) for skin cancer associated with a high cumulative dose (\u2265150\u00a0g) or long\u2010term use (\u22655\u00a0years) of azathioprine, adjusted for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> cases and 360 matched controls were identified. Ever use of azathioprine was associated with a considerably increased risk of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a03.3, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.5\u20137.3) that was even more apparent in patients with high cumulative dose (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7\u201312.5) or long\u2010term (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.8; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7\u201313.6) use of azathioprine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Azathioprine use in patients with myasthenia is associated with an increased risk of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12329","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T08:05:13Z","timestamp":1387181113000},"page":"454-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Risk of non\u2010melanoma skin cancer in myasthenia patients treated with azathioprine"],"prefix":"10.1111","volume":"21","author":[{"given":"E. G.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Health Sciences Odense University Hospital and Institute of Clinical Research University of Southern Denmark (SDU) Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Clinical Pharmacology SDU Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hallas","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Clinical Pharmacology SDU Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Friis","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Centre and Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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