{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:38:22Z","timestamp":1768523902957,"version":"3.49.0"},"reference-count":4,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC010367"],"award-info":[{"award-number":["R01 DC010367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>A subset of patients with <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) present with early and prominent language deficits. It is unclear whether the burden of underlying \u03b2\u2010amyloid pathology is associated with language or general cognitive impairment in these subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The relationship between cortical \u03b2\u2010amyloid burden on [<jats:sup>11<\/jats:sup><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>]<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ittsburgh compound <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>) positron emission tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>) and performance on the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ontreal <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ognitive <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>), the <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>echsler <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>emory <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale \u2212 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hird <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>dition (<jats:styled-content style=\"fixed-case\">WMS<\/jats:styled-content>\u2010III), the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>oston <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>aming <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>est (<jats:styled-content style=\"fixed-case\">BNT<\/jats:styled-content>) and the <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>phasia <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>attery (<jats:styled-content style=\"fixed-case\">WAB<\/jats:styled-content>) was assessed using regression and correlation analyses in subjects presenting with aphasia who showed \u03b2\u2010amyloid deposition on <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">B PET<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The global <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> ratio was inversely correlated with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and the <jats:styled-content style=\"fixed-case\">WMS<\/jats:styled-content>\u2010III <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>isual <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eproduction (<jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>) subtest (<jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content> I, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.02; <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content> II, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). However, the correlations between <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> ratio, <jats:styled-content style=\"fixed-case\">BNT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.13), <jats:styled-content style=\"fixed-case\">WAB<\/jats:styled-content> aphasia quotient (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.11) and <jats:styled-content style=\"fixed-case\">WAB<\/jats:styled-content> repetition scores (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.34) were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that an increased cortical \u03b2\u2010amyloid burden is associated with cognitive impairment, but not language deficits, in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> subjects presenting with aphasia. The results suggest that \u03b2\u2010amyloid deposition could be partly contributing to impaired cognition in such patients whilst language dysfunction may be more influenced by other pathological mechanisms, perhaps downstream pathways of \u03b2\u2010amyloid deposition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12331","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T08:05:18Z","timestamp":1387181118000},"page":"1040-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Amyloid burden correlates with cognitive decline in <scp>A<\/scp>lzheimer's disease presenting with aphasia"],"prefix":"10.1111","volume":"21","author":[{"given":"Y.","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Whitwell","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Machulda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology (Neuropsychology) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Senjem","sequence":"additional","affiliation":[{"name":"Department of Information Technology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"C. R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"Josephs","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000287073.12737.35"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm336"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22248"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.666"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12331","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:34:31Z","timestamp":1695555271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":4,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/ene.12331"],"URL":"https:\/\/doi.org\/10.1111\/ene.12331","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]},"assertion":[{"value":"2013-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}