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Boundaries in <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> numbers have been found between healthy people with and without risk to pass the disorder to the next generation, and between people without, with a mild, or with a fully penetrant phenotype. These data have been generated in western populations and it is not clear whether they are also valid amongst Chinese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In order to establish normative data in the huntingtin gene for Chinese people, 966 chromosomes from normal controls were tested. Further, the range of <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> repeats was examined in a cohort from six centres and a total of 368 patients with the disease were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> triplet repeat range in normal controls was between 9 and 35 (mean 18.9, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 2.57). Triplets in the range between 26 and 35 were found in 2.5%. In the patient cohort, triplet repeats in the shorter allele were between 8 and 37 (mean 17.7, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 1.6). In the longer allele, a range between 36 and 120 was found. There was a negative correlation (\u22120.65, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.42) between age at onset and the number of triplet repeats in the larger allele. The mean age at onset was 38\u00a0years, with a range between 2 and 70\u00a0years. In 23 patients (6%) a childhood or juvenile onset was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data show comparable ranges of huntingtin gene <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> triplet repeats in normal people and in patients with Huntington's disease as in western populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12366","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T12:42:54Z","timestamp":1390912974000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Huntingtin gene <scp>CAG<\/scp> repeat numbers in <scp>C<\/scp>hinese patients with <scp>H<\/scp>untington's disease and controls"],"prefix":"10.1111","volume":"21","author":[{"given":"H.","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurology Xiangya Hospital Central South University Changsha China"},{"name":"Key Laboratory of Hunan Province in Neurodegenerative Disorders State Key Laboratory of Medical Genetics of China Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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