{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:28:20Z","timestamp":1789500500483,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Obesity is associated with the risk of coronary artery disease and stroke. Visceral fat plays a significant role in the atherogenic effects of obesity. Whether visceral fat accumulation, as measured by computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>), is an independent risk factor for the presence of cerebral small vessel disease (<jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>) was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study comprised 506 Japanese subjects 35\u201374\u00a0years of age (mean 55.3\u00a0years) without a history of symptomatic cerebrovascular disease who underwent health screening tests, including brain magnetic resonance imaging, carotid echography and measurements of the visceral fat area (<jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content>) and subcutaneous fat area (<jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>) on abdominal <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Visceral fat accumulation was defined as <jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content> \u2265 100\u00a0cm<jats:sup>2<\/jats:sup>. Logistic regression analysis was performed to examine the associations between visceral fat accumulation and cerebral <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> such as white matter lesions (<jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s) and silent lacunar infarction (<jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> but not carotid plaque were significantly higher in subjects with <jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content> \u2265 100\u00a0cm<jats:sup>2<\/jats:sup> than those with <jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content> &lt; 100\u00a0cm<jats:sup>2<\/jats:sup>. A <jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content> \u2265 100\u00a0cm<jats:sup>2<\/jats:sup> was associated with <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> independent of age, cardiovascular risk factors and other measurements of obesity, such as waist circumference and body mass index. A large waist circumference was independently associated with <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>, the combination of <jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>, and body mass index were not associated with <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s or <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Visceral fat accumulation was independently associated with the presence of cerebral <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> in subjects without a history of symptomatic cerebrovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12374","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T06:25:35Z","timestamp":1391581535000},"page":"667-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Visceral fat accumulation is associated with cerebral small vessel disease"],"prefix":"10.1111","volume":"21","author":[{"given":"K.","family":"Yamashiro","sequence":"first","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Rinkai Hospital Tokyo 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