{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:32:26Z","timestamp":1789716746649,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health and Welfare, Republic of Korea","award":["HIC120713"],"award-info":[{"award-number":["HIC120713"]}]},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["HI10C2020"],"award-info":[{"award-number":["HI10C2020"]}]},{"DOI":"10.13039\/501100004084","name":"Korean Science and Engineering Foundation (KOSEF)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004084","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean Government","award":["2011-0028333"],"award-info":[{"award-number":["2011-0028333"]}]},{"name":"Samsung Medical Center Clinical Research Development Program","award":["CRL-108011"],"award-info":[{"award-number":["CRL-108011"]}]},{"name":"Samsung Medical Center Clinical Research Development Program","award":["CRS 110-14-1"],"award-info":[{"award-number":["CRS 110-14-1"]}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"crossref","award":["2013K000338"],"award-info":[{"award-number":["2013K000338"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Background and purpose<\/jats:title>\n \n The progression pattern of brain structural changes in patients with isolated cerebrovascular disease (\n CVD<\/jats:styled-content>\n ) remains unclear. To investigate the role of isolated\n CVD<\/jats:styled-content>\n in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (sv\n MCI<\/jats:styled-content>\n ) and pure subcortical vascular dementia (\n SV<\/jats:styled-content>\n aD) patients were characterized.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty\u2010five patients with sv\n MCI<\/jats:styled-content>\n and 46 patients with\n SV<\/jats:styled-content>\n aD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (\n NC<\/jats:styled-content>\n ) were recruited.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with\n NC<\/jats:styled-content>\n , patients with PiB(\u2212) sv\n MCI<\/jats:styled-content>\n exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(\u2212)\n SV<\/jats:styled-content>\n aD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with\n NC<\/jats:styled-content>\n , patients with PiB(\u2212) sv\n MCI<\/jats:styled-content>\n exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(\u2212)\n SV<\/jats:styled-content>\n aD. Compared with\n NC<\/jats:styled-content>\n subjects, patients with PiB(\u2212) sv\n MCI<\/jats:styled-content>\n exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(\u2212)\n SV<\/jats:styled-content>\n aD exhibited additional deformities within the lateral head and inferior body.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our findings suggest that patients with\n CVD<\/jats:styled-content>\n in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.12376","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T18:04:28Z","timestamp":1391537068000},"page":"744-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type"],"prefix":"10.1111","volume":"21","author":[{"given":"H. 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