{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T14:52:12Z","timestamp":1774709532364,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Odense University Hospital"},{"DOI":"10.13039\/501100006356","name":"University of Southern Denmark","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Savvaerkejer Jeppe Juhl og hustru Ovita Juhls Mindelegat"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To evaluate the association between having non\u2010thymoma myasthenia and the risk of extra\u2010thymic cancer in a population\u2010based setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide case\u2013control study was conducted in Denmark based on medical registries. The study included all cases with a first time diagnosis of cancer during 2000\u20132009. Each case was matched by birth year and gender with eight population controls using risk set sampling. Subjects with myasthenia were identified through a validated register\u2010based algorithm. Conditional logistic regression was used to compute crude and adjusted odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s), with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s), for cancer associated with a prior diagnosis of myasthenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 233\u00a0437 cases and 1\u00a0867\u00a0009 controls were identified. A total of 80 cases and 518 controls had a prior diagnosis of myasthenia. Myasthenia was not associated with an increased risk of overall cancer (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.1; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.9\u20131.4). Adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s for major cancer sites were also close to unity, whereas an elevated risk of lymphomas was observed (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.0; 95% CI 0.8\u20135.5). Early\u2010onset myasthenia was associated with a slightly increased <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for overall cancer (1.5; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20132.3); however, this estimate was based on small numbers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010thymoma myasthenia was not associated with an increased risk of overall cancer. Larger studies are necessary to evaluate the association between myasthenia and risk of lymphoma and the potential effect modification by age of myasthenia onset in relation to cancer risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12383","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T13:31:59Z","timestamp":1393421519000},"page":"773-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Myasthenia and risk of cancer: a population\u2010based case\u2013control study"],"prefix":"10.1111","volume":"21","author":[{"given":"E. G.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Neurology Odense University Hospital and Institute of Clinical Research Faculty of Health Sciences University of Southern Denmark (SDU) Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Clinical Pharmacology University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hallas","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Clinical Pharmacology University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Friis","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Centre and Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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