{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:08:55Z","timestamp":1787724535068,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Background and purpose<\/jats:title>Impairment of cognitive functions occurs in essential tremor (ET<\/jats:styled-content>) although the mechanism is largely unknown. A possible association between cognitive performance and brain atrophy in ET<\/jats:styled-content> patients was examined using neuropsychological tests and voxel\u2010based morphometry (VBM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010five patients with ET<\/jats:styled-content> and 25 matched healthy controls were evaluated. ET<\/jats:styled-content> was diagnosed using the National Institutes of Health collaborative genetic criteria. Severity of tremor was assessed using the Fahn\u2212Tolosa\u2212Marin (FTM<\/jats:styled-content>) tremor rating scale. Subjects were assessed using a structured neuropsychological battery. Brain images were acquired using a 3T magnetic resonance imaging scanner. VBM<\/jats:styled-content> analysis was performed using Statistical Parametric Mapping 8.<\/jats:p><\/jats:sec>Results<\/jats:title>The age of the patients was 45.0\u00a0\u00b1\u00a010.7 years and of controls 45.4\u00a0\u00b1\u00a010.7\u00a0years. Tremor duration was 9.84\u00a0\u00b1\u00a06.63\u00a0years and total FTM<\/jats:styled-content> score was 37.34\u00a0\u00b1\u00a017.67. Patients were divided into two groups: ETCI<\/jats:styled-content> with cognitive impairment (three or more abnormal neuropsychological tests, 1.5 standard deviation criterion) and ETNCI<\/jats:styled-content> without cognitive impairment. Compared with controls, the ETCI<\/jats:styled-content> group had significantly impaired performance in neuropsychological tests. One\u2010way analysis of variance was performed between the three groups (ETCI<\/jats:styled-content>, ETNCI<\/jats:styled-content>, controls) followed by the two\u2010sample t<\/jats:italic> test. Compared with controls, grey matter volume (GMV<\/jats:styled-content>) loss was observed in ETCI<\/jats:styled-content> in the cerebellum (anterior and posterior lobes) and medial frontal gyrus. GMV<\/jats:styled-content> loss was observed in ETCI<\/jats:styled-content> compared with ETNCI<\/jats:styled-content> in the medial frontal gyrus, post central gyrus, anterior cingulate and insula. Impairment in neuropsychological tests significantly correlated with GMV<\/jats:styled-content> of the medial frontal gyrus, superior parietal lobe, middle temporal gyrus, occipital lobe, lentiform nucleus, insular and cingulate cortices and cerebellum posterior lobe in ETCI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A correlation between neurocognitive deficits in ETCI<\/jats:styled-content> and GMV<\/jats:styled-content> was observed suggesting that grey matter atrophy appears to be a correlate of cognitive impairment in ET<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12399","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T05:30:53Z","timestamp":1394515853000},"page":"874-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Association between cortical volume loss and cognitive impairments in essential tremor"],"prefix":"10.1111","volume":"21","author":[{"given":"K. 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