{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:08:55Z","timestamp":1759133335876},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Anti\u2010\u03b22\u2010glycoprotein I (anti\u2010\u03b22\u2010GPI) antibodies are part of the heterogeneous family of antiphospholipid antibodies and seem to be present in various neurological manifestations in addition to antiphospholipid syndrome (<jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>). Our objective was to analyse the clinical, radiological and therapeutic characteristics of neurological patients with positive anti\u2010\u03b22\u2010GPI antibodies and without the Sapporo criteria for <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records were retrospectively reviewed of 28 consecutive patients hospitalized in the Neurology Department of Strasbourg University Hospital, France, in whom anti\u2010\u03b22\u2010<jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content> antibodies (immunoglobulin G and\/or immunoglobulin M) were positive and other antiphospholipid antibodies negative, from November 2005 to July 2011. Clinical, radiological, biological and therapeutic data and clinical course were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive anti\u2010\u03b22\u2010GPI antibodies were present in 28 patients. The predominant physiopathological process was mainly inflammatory (25% with myelitis, 14.3% with optic neuritis) or vascular (14.3% with cerebral ischaemia, 7.1% with cerebral vasculitis). Brain magnetic resonance imaging was performed in 89.3% of patients: atypical lesions were observed in 44% and typical inflammatory and vascular lesions in 16% and 12%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anti\u2010\u03b22\u2010GPI antibody seems to be involved in two types of neurological disease: vascular or inflammatory \u2018multiple sclerosis\u2010like\u2019 disease. These two types of patients frequently develop an autoimmune disease (multiple sclerosis, systemic lupus erythematosus, APS). However, a large proportion of the patients had an undefined profile with aspecific cerebral lesions and required monitoring. This study raises questions about a separate entity at the border between APS and multiple sclerosis which remains to be better defined in a larger cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12408","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T14:17:50Z","timestamp":1396448270000},"page":"901-906","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Isolated anti\u2010\u03b22\u2010glycoprotein I antibodies in neurology: a frontier syndrome between multiple sclerosis and antiphospholipid syndrome?"],"prefix":"10.1111","volume":"21","author":[{"given":"M.","family":"Renaud","sequence":"first","affiliation":[{"name":"Service of Neurology University Hospital of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Aupy","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Uring\u2010Lambert","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology University Hospital of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010B.","family":"Chanson","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Collongues","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Blanc","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"De S\u00e8ze","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90237-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.12.1247"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.8.1181"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.8.1701"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.384"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.4.517"},{"key":"e_1_2_7_8_1","first-page":"251","article-title":"Autoimmune diseases associated with transverse myelitis","volume":"50","author":"Tristano AG","year":"2009","journal-title":"Rev Invest Clin"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0399-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200001000-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.09.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.05.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg080"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-002-8287-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.05.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.12.3079-b"},{"key":"e_1_2_7_17_1","first-page":"747","article-title":"Lupoid sclerosis with antiphospholipid and antimyelin antibodies","volume":"20","author":"Marullo S","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00200.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1055\/s-0038-1649577","article-title":"Anticardiolipin antibodies block the inhibition by \u03b22\u2010glycoprotein I of the factor Xa generating activity of platelets","volume":"70","author":"Shi W","year":"1993","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310361352"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/berh.1999.0083"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199805)41:5<800::AID-ART5>3.0.CO;2-J"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270289"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0755-4982(04)98805-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.08.007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-129627"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:50:21Z","timestamp":1695552621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,2]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/ene.12408"],"URL":"https:\/\/doi.org\/10.1111\/ene.12408","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,2]]},"assertion":[{"value":"2013-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}