{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:06:35Z","timestamp":1772708795641,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30870860"],"award-info":[{"award-number":["30870860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Metabolic syndrome (MetS) has been reported to be associated with silent lacunar infarction, which is highly related to white matter lesions (<jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s). However, little is known about the relationship between MetS and the prevalence of <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s. The association between MetS, its components and <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s in middle\u2010aged and elderly patients was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients aged 50\u00a0years and older were prospectively enrolled in this study. All participants underwent magnetic resonance imaging scans to assess the presence and severity of <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s. The MetS was defined according to the updated National Cholesterol Education Program's Adult Treatment Panel <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria. Multivariate logistic regression analyses were performed to examine the relationship between MetS, its components and <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 852 patients were enrolled in the study. MetS was present in 38.4%. MetS was associated with an increased risk of periventricular <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">PVWML<\/jats:styled-content>s) and deep <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">DWML<\/jats:styled-content>s) after multivariable adjustment (odds ratio 3.21, 95% confidence interval 2.26\u20134.55 for <jats:styled-content style=\"fixed-case\">PVWML<\/jats:styled-content>s; odds ratio 2.93, 95% confidence interval 2.09\u20134.09 for <jats:styled-content style=\"fixed-case\">DWML<\/jats:styled-content>s). Amongst MetS components, elevated blood pressure, elevated fasting blood glucose and low high density lipoprotein cholesterol were associated with <jats:styled-content style=\"fixed-case\">PVWML<\/jats:styled-content>s, whilst elevated blood pressure and low high density lipoprotein cholesterol were related to <jats:styled-content style=\"fixed-case\">DWML<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate that MetS is associated with the prevalence of <jats:styled-content style=\"fixed-case\">PVWML<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">DWML<\/jats:styled-content>s independent of other risk factors in middle\u2010aged and elderly patients. The association between MetS as a cluster and <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s was not driven by MetS components.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12433","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T14:35:40Z","timestamp":1396449340000},"page":"1032-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association between metabolic syndrome and white matter lesions in middle\u2010aged and elderly patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Z.\u2010G.","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Neurology Daping Hospital Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology Daping Hospital Third Military Medical University Chongqing 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