{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:13:14Z","timestamp":1769112794598,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Contrat de Projet Etat-Region 2007"},{"name":"Maire Taponen Foundation"},{"DOI":"10.13039\/501100007361","name":"Aarne and Aili Turunen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007361","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014062","name":"Lilly Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008969","name":"Alfred Kordelin Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008969","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007083","name":"Orion Farmos Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010129","name":"Maud Kuistila Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008320","name":"Finnish Brain Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008320","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003756","name":"Biomedicum Helsinki Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003756","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Projet Hospitalier de Recherche Clinique R\u00e9gional"},{"name":"Centre National de Genotypage"},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"crossref"}]},{"name":"G\u00e9nop\u00f4le de Lille"},{"name":"Adrinord"},{"name":"EA2691"},{"name":"Institut Pasteur de Lille"},{"name":"INSERM U744"},{"name":"Basel Stroke-Funds"},{"name":"K\u00e4the-Zingg-Schwichtenberg-Fonds of the Swiss Academy of Medical Sciences"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["33CM30-124119"],"award-info":[{"award-number":["33CM30-124119"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["33CM30-140340\/1"],"award-info":[{"award-number":["33CM30-140340\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss Heart Foundation"},{"DOI":"10.13039\/501100004756","name":"Emil Aaltonen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Paavo Ilmari Ahvenainen Foundation"},{"name":"Helsinki University Central Hospital Research Fund"},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Helsinki University Medical Foundation"},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki and Sakari Sohlberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010133","name":"Aarne Koskelo Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010133","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Patients with ischaemic stroke (<jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>) caused by a spontaneous cervical artery dissection (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and in those with ischaemic stroke attributable to other (non\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) causes were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The frequency of stroke in first\u2010degree relatives (family history of stroke, <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>) was studied in <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> patients (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients and age\u2010 and sex\u2010matched non\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients) from the Cervical Artery Dissection and Ischemic Stroke Patients (<jats:styled-content style=\"fixed-case\">CADISP<\/jats:styled-content>) database. <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0\u2264\u00a050 and <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0&gt;\u00a050 were defined as having relatives who suffered stroke at the age of \u226450 or &gt;50\u00a0years. <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0\u2264\u00a050 and <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0&gt;\u00a050 were studied in Ce<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and non\u2010Ce<jats:styled-content style=\"fixed-case\">AD IS<\/jats:styled-content> patients and related to age, sex, number of siblings, hypertension, hypercholesterolemia, smoking and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 1225 patients were analyzed. <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0\u2264\u00a050 was less frequent in Ce<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients (15\/598\u00a0=\u00a02.5%) than in non\u2010Ce<jats:styled-content style=\"fixed-case\">AD IS<\/jats:styled-content> patients (38\/627\u00a0=\u00a06.1%) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003; odds ratio 0.40, 95% confidence interval 0.22\u20130.73), also after adjustment for age, sex and number of siblings (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005; odds ratio 0.42, 95% confidence interval 0.23\u20130.77). The frequency of <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0&gt;\u00a050 was similar in both study groups. Vascular risk factors did not differ between patients with positive or negative <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0\u2264\u00a050. However, patients with <jats:styled-content style=\"fixed-case\">FHS<\/jats:styled-content>\u00a0&gt;\u00a050 were more likely to have hypertension and higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Relatives of Ce<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients had fewer strokes at a young age than relatives of non\u2010Ce<jats:styled-content style=\"fixed-case\">AD IS<\/jats:styled-content> stroke patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12437","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T14:36:11Z","timestamp":1396449371000},"page":"1102-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stroke in first\u2010degree relatives of patients with cervical artery dissection"],"prefix":"10.1111","volume":"21","author":[{"given":"M.","family":"Kloss","sequence":"first","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"},{"name":"Department of Neurosurgery Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Grond\u2010Ginsbach","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pezzini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Neurology Clinic University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-0094","authenticated-orcid":false,"given":"T. M.","family":"Metso","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Metso","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Debette","sequence":"additional","affiliation":[{"name":"Department of Neurology H\u00f4pital Lariboisi\u00e8re Paris France"},{"name":"Department of Neurology University Lille Nord de France Lille France"},{"name":"Department of Epidemiology and Public Health INSERM U744 Pasteur Institute Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Leys","sequence":"additional","affiliation":[{"name":"Department of Neurology University Lille Nord de France Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Dallongeville","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health INSERM U744 Pasteur Institute Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Caso","sequence":"additional","affiliation":[{"name":"Stroke Unit Perugia University Hospital Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Thijs","sequence":"additional","affiliation":[{"name":"Department of Neurosciences VIB \u2013 Vesalius Research Center Experimental Neurology \u2013 Laboratory of Neurobiology KU Leuven \u2013 University of Leuven Leuven Belgium"},{"name":"Neurology University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bersano","sequence":"additional","affiliation":[{"name":"Cerebrovascular Unit IRCCS Foundation C. Besta Neurological Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Touz\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Caen Basse Normandie INSERM U919 CHU C\u00f4te de Nacre Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Bonati","sequence":"additional","affiliation":[{"name":"Department of Neurology Basel University Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tatlisumak","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010L.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Lyrer","sequence":"additional","affiliation":[{"name":"Department of Neurology Basel University Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. T.","family":"Engelter","sequence":"additional","affiliation":[{"name":"Department of Neurology Basel University Hospital Basel Switzerland"},{"name":"Neurorehabilitation Unit University Center for Medicine of Aging and Rehabilitation Felix Platter Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70084-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.529883"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.665190"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.000125"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318293e2eb"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0839-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.1.24"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.231902"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.82"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000244486.30455.71"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000094325.95097.86"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2009.00281.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000121646.23955.0f"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000158920.67013.53"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088668"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10558"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.842"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12073"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002108"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990188"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.575"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828ab2ed"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12437","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:20:49Z","timestamp":1695572449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,2]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/ene.12437"],"URL":"https:\/\/doi.org\/10.1111\/ene.12437","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,2]]},"assertion":[{"value":"2014-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}