{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:53:27Z","timestamp":1790420007464,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Differentiating idiopathic <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's disease from secondary parkinsonian syndromes is crucial since their management and prognosis differ considerably. Functional imaging of the dopaminergic pathway by means of [\u00b9\u00b2\u00b3I]<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CIT SPECT<\/jats:styled-content> (Da<jats:styled-content style=\"fixed-case\">TSCAN<\/jats:styled-content>) might be useful in this regard, but its role is still controversial. The accuracy of Da<jats:styled-content style=\"fixed-case\">TSCAN<\/jats:styled-content> in the differential diagnosis between Parkinson's disease and vascular or drug\u2010induced parkinsonism was therefore systematically reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content> were searched for studies aiming to determine accuracy measures (sensitivity, specificity, diagnostic odds ratio, positive and negative likelihood ratios) of Da<jats:styled-content style=\"fixed-case\">TSCAN<\/jats:styled-content> in differentiating between Parkinson's disease and vascular or drug\u2010induced parkinsonism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five studies were included. Pooled accuracy measures in differentiating between Parkinson's disease and vascular or drug\u2010induced parkinsonism were relatively high, with sensitivity and specificity values above 85% and 80%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Da<jats:styled-content style=\"fixed-case\">TSCAN<\/jats:styled-content> might accurately differentiate between early Parkinson's disease and secondary parkinsonian conditions, namely vascular or drug\u2010induced, in patients with clinically unclear parkinsonism. However, all the studies reviewed here show several methodological limits, which prevent definitive conclusions on the role of Da<jats:styled-content style=\"fixed-case\">TSCAN<\/jats:styled-content> being drawn in this context. Further studies are needed to confirm our results and definitely evaluate the utility of Da<jats:styled-content style=\"fixed-case\">TSCAN<\/jats:styled-content> in differentiating between Parkinson's disease and vascular or drug\u2010induced parkinsonism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12444","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T07:46:36Z","timestamp":1398843996000},"page":"1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["[\u00b9\u00b2\u00b3I]<scp>FP<\/scp>\u2010<scp>CIT SPECT<\/scp> (Da<scp>TSCAN<\/scp>) may be a useful tool to differentiate between <scp>P<\/scp>arkinson's disease and vascular or drug\u2010induced parkinsonisms: a meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"F.","family":"Brigo","sequence":"first","affiliation":[{"name":"Divisione di Neurologia Ospedale \u2018Franz Tappeiner\u2019 Merano Italy"},{"name":"Dipartimento di Scienze Neurologiche e del Movimento Universit\u00e0 di Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Matinella","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Neurologiche e del Movimento Universit\u00e0 di Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Erro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Neurologiche e del Movimento Universit\u00e0 di Verona Verona Italy"},{"name":"Sobell Department of Motor Neuroscience and Movement Disorders University College London (UCL) Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tinazzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Neurologiche e del Movimento Universit\u00e0 di Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100031814"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540020018011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1497"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050374"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(08)70042-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-7-27"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-3-200402030-00010"},{"key":"e_1_2_8_10_1","first-page":"17","article-title":"The role of molecular imaging in the differential diagnosis of parkinsonism","volume":"56","author":"Booij J","year":"2012","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20141"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00736-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22098"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.03.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.06.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-6-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.11.1061"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90128-V"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-2-9"},{"key":"e_1_2_8_21_1","unstructured":"ZamoraJ MurielA AbrairaV.Statistical methods.2006. 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