{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:00:57Z","timestamp":1790791257988,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Sensitivity to light (photophobia) is a common ill\u2010understood symptom of migraine, whose neurobiology is important in understanding the disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients reporting premonitory symptoms before migraine headache were infused with nitroglycerin (<jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content>) at a first visit. Patients who responded with premonitory symptoms followed by a delayed headache resembling their migraine had positron emission tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>) scans at least 1\u00a0week later, during which <jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content> infusion was repeated. H<jats:sub>2<\/jats:sub><jats:sup>15<\/jats:sup>O <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> scans were performed during baseline (pain free), premonitory phase (pain free) and migraine headache. Patients were divided into two groups, with and without photophobia in the premonitory phase. The differences between the premonitory and baseline scans were analysed within groups and between groups using statistical parametric mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients participated in the <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> study, 10 of whom had at least one <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> scan during the premonitory phase in the absence of pain. Data from these 10 patients were included in the final analysis. Five patients had photophobia and five patients did not have photophobia in the premonitory phase. Comparing the premonitory scans to baseline scans, there was activation of extrastriate visual cortex (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>18) in patients with photophobia. This activation was significantly greater than in the patients without photophobia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that photic hypersensitivity is linked to activation of the visual cortex during the premonitory phase of migraine in the absence of headache.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12451","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T07:48:36Z","timestamp":1398844116000},"page":"1178-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Photic hypersensitivity in the premonitory phase of migraine \u2013 a positron emission tomography study"],"prefix":"10.1111","volume":"21","author":[{"given":"F. 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