{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:16:22Z","timestamp":1780632982094,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T00:00:00Z","timestamp":1400284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Background and purpose<\/jats:title>Although the latest recommendations suggest that carotid endarterectomy (CEA<\/jats:styled-content>) should be performed in symptomatic carotid artery stenosis (sCAS<\/jats:styled-content>) patients within 2\u00a0weeks of the index event, only a minority of patients undergo surgery within the recommended time\u2010frame. The aim of this international multicenter study was to prospectively evaluate the safety of early CEA<\/jats:styled-content> in patients with sCAS<\/jats:styled-content> in everyday clinical practice settings.<\/jats:p><\/jats:sec>Methods<\/jats:title>Consecutive patients with non\u2010disabling acute ischaemic stroke (AIS<\/jats:styled-content>) or transient ischaemic attack (TIA<\/jats:styled-content>) due to sCAS<\/jats:styled-content> (\u226570%) underwent early (\u226414\u00a0days) CEA<\/jats:styled-content> at five tertiary\u2010care stroke centers during a 2\u2010year period. Primary outcome events included stroke, myocardial infarction (MI<\/jats:styled-content>) or death occurring during the 30\u2010day follow\u2010up period and were defined according to the I<\/jats:styled-content>nternational C<\/jats:styled-content>arotid S<\/jats:styled-content>tenting S<\/jats:styled-content>tudy criteria.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 165 patients with sCAS<\/jats:styled-content> [mean age 69\u00a0\u00b1\u00a010\u00a0years; 69% men; 70% AIS; 6% crescendo TIA<\/jats:styled-content>; 8% with contralateral internal carotid artery (ICA<\/jats:styled-content>) occlusion] underwent early CEA<\/jats:styled-content> (median elapsed time from symptom onset 8\u00a0days). Urgent CEA<\/jats:styled-content> (\u22642\u00a0days) was performed in 20 cases (12%). The primary outcomes of stroke and MI<\/jats:styled-content> were 4.8% [95% confidence interval (CI<\/jats:styled-content>) 1.5%\u20138.1%] and 0.6% (95% CI<\/jats:styled-content> 0%\u20131.8%). The combined outcome event of non\u2010fatal stroke, non\u2010fatal MI<\/jats:styled-content> or death was 5.5% (95% CI<\/jats:styled-content> 2.0%\u20139.0%). Crescendo TIA<\/jats:styled-content>, contralateral ICA<\/jats:styled-content> occlusion and urgent CEA<\/jats:styled-content> were not associated (P<\/jats:italic>\u00a0>\u00a00.2) with a higher 30\u2010day stroke rate.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings indicate that the risk of early CEA<\/jats:styled-content> in consecutive unselected patients with non\u2010disabling AIS<\/jats:styled-content> or TIA<\/jats:styled-content> due to sCAS<\/jats:styled-content> is acceptable when the procedure is performed within 2\u00a0weeks (or even within 2\u00a0days) from symptom onset.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12461","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T14:15:11Z","timestamp":1400336111000},"page":"1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Safety of early endarterectomy in patients with symptomatic carotid artery stenosis: an international multicenter study"],"prefix":"10.1111","volume":"21","author":[{"given":"G.","family":"Tsivgoulis","sequence":"first","affiliation":[{"name":"Second Department of Neurology \u2018Attikon\u2019 Hospital University of Athens School of Medicine Athens Greece"},{"name":"Department of Neurology Democritus University of Thrace School of Medicine Alexandroupolis Greece"},{"name":"International Clinical Research Center St Anne's University Hospital in Brno Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Krogias","sequence":"additional","affiliation":[{"name":"Department of Neurology St Josef Hospital Ruhr University Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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H.","family":"Meves","sequence":"additional","affiliation":[{"name":"Department of Neurology St Josef Hospital Ruhr University Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Voumvourakis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology \u2018Attikon\u2019 Hospital University of Athens School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Har\u0161\u00e1ny","sequence":"additional","affiliation":[{"name":"International Clinical Research Center St Anne's University Hospital in Brno Brno Czech Republic"},{"name":"Department of Neurology St Anne's University Hospital and Medical Faculty of Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Staffa","sequence":"additional","affiliation":[{"name":"2nd Department of Surgery St Anne's University Hospital, and Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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