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Although memory difficulties are commonly endorsed, few reports of <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s inclusively assess all cognitive domains in detail. Our aim was to perform an unbiased cognitive evaluation of <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> patients with voltage\u2010gated potassium channel complex antibodies (<jats:styled-content style=\"fixed-case\">VGKC<jats:sub>C<\/jats:sub><\/jats:styled-content>\u2010Abs) in order to delineate cognitive strengths and weaknesses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serial <jats:styled-content style=\"fixed-case\">VGKC<jats:sub>C<\/jats:sub><\/jats:styled-content>\u2010Ab <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) were assessed with a comprehensive evaluation of memory, executive functions, visuospatial skills and language. Clinical magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a010\/12) was evaluated. Five subjects had serial cognitive testing available, permitting descriptive analysis of change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects demonstrated mild to moderate impairment in memory (mean <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u22121.9) and executive functions (mean <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u22121.5), with variable impairments in language and sparing of visuospatial skills. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings showed T2 hyperintensities in medial temporal lobe (10\/10) and basal ganglia (2\/10). Serial cognitive examination revealed heterogeneity in cognitive function; whereas most patients improved in one or more domains, residual impairments were observed in some patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study augments previous neuropsychological analyses in <jats:styled-content style=\"fixed-case\">VGKC<jats:sub>C<\/jats:sub><\/jats:styled-content>\u2010Ab <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> by identifying not only memory and executive function deficits but also language impairments, with preservation of visuospatial functioning. The study further highlights the importance of domain\u2010specific testing to parse out the complex cognitive phenotypes of <jats:styled-content style=\"fixed-case\">VGKC<jats:sub>C<\/jats:sub><\/jats:styled-content>\u2010Ab <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12482","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T05:09:44Z","timestamp":1404277784000},"page":"1301-1310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["More than memory impairment in voltage\u2010gated potassium channel complex encephalopathy"],"prefix":"10.1111","volume":"21","author":[{"given":"B. M.","family":"Bettcher","sequence":"first","affiliation":[{"name":"Department of Neurology Memory and Aging Center UCSF San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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