{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T14:02:23Z","timestamp":1717423343360},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Institute for Health Research HIV\/AIDS Priority Fellowship Grant","award":["201202"],"award-info":[{"award-number":["201202"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To our knowledge there are no studies reporting the use and short\u2010term outcomes of intravenous tissue plasminogen activator (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content>) for the treatment of acute ischaemic stroke (<jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content>) in people living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The US Nationwide Inpatient Sample (<jats:styled-content style=\"fixed-case\">NIS<\/jats:styled-content>) (2006\u20132010) was searched for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">NIS<\/jats:styled-content>, 2.2% (62\/2877) of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> cases were thrombolyzed with <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> (median age 52\u00a0years, range 27\u201378, 32% female, 22% Caucasian) vs. 2.1% (19\u00a0335\/937\u00a0896) of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010uninfected cases (median age 72\u00a0years, range 17\u2013102\u00a0years, 50% female, 74% Caucasian; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.77). There were more deaths in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected versus uninfected patients with stroke (220\/2877, 7.6% vs. 49\u00a0089\/937\u00a0547, 5.2%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) but no difference in the proportion of deaths amongst <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content>\u2010treated patients. The age\u2010 and sex\u2010adjusted odds ratio for death following <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> administration in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected versus uninfected patients was 2.26 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.12, 4.58), but the interaction on mortality between <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> use was not statistically significant, indicating no difference in risk of in\u2010hospital death by <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> serostatus with <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> use. A higher number of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients remained in hospital versus died or were discharged at both 10 and 30\u00a0days (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 at 10 and 30\u00a0days). No difference in the proportion of intracerebral hemorrhage in the two groups was found (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.362).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The in\u2010hospital mortality is higher amongst <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected <jats:styled-content style=\"fixed-case\">AIS<\/jats:styled-content> patients than <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010uninfected patients. However, the risk of death amongst <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients treated with <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TPA<\/jats:styled-content> is similar to <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010uninfected groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12506","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T12:17:55Z","timestamp":1404994675000},"page":"1394-1399","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcomes of intravenous tissue plasminogen activator for acute ischaemic stroke in <scp>HIV<\/scp>\u2010infected adults"],"prefix":"10.1111","volume":"21","author":[{"given":"E. M.","family":"Sweeney","sequence":"first","affiliation":[{"name":"Department of Biostatistics Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. T.","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins Hospital Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Section of Infections of the Nervous System NINDS National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Z.","family":"Willey","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Cervantes\u2010Arslanian","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Uchino","sequence":"additional","affiliation":[{"name":"Cerebrovascular Center Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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