{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:53:53Z","timestamp":1773975233942,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171099"],"award-info":[{"award-number":["81171099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000501"],"award-info":[{"award-number":["81000501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Background and purpose<\/jats:title>Susceptibility\u2010weighted imaging (SWI<\/jats:styled-content>) is a high spatial resolution technique that can indirectly demonstrate increased cerebral oxygen extraction. Our aim was to assess whether asymmetric cortical vessel sign (ACVS<\/jats:styled-content>) on SWI<\/jats:styled-content> could be associated with early neurological deterioration (END<\/jats:styled-content>) as well as 90\u2010day unfavorable outcome in patients with acute ischaemic stroke.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Consecutive patients with acute middle cerebral artery (MCA<\/jats:styled-content>) territory infarction were prospectively enrolled. ACVS<\/jats:styled-content> was defined as more and\/or larger vessels with greater signal loss than those in the opposite hemisphere on minimum intensity projection of SWI<\/jats:styled-content>. The neurofunctional fluctuation during acute phase as well as 90\u2010day outcomes were assessed. A National Institutes of Health Stroke Scale increment \u22652 points and \u22654 points despite standard treatment in the first 72\u00a0h after admission was defined as END<\/jats:styled-content>2 and END<\/jats:styled-content>4, respectively.<\/jats:p><\/jats:sec>Results<\/jats:title>In all, 572 patients were finally enrolled. ACVS<\/jats:styled-content> on SWI<\/jats:styled-content> was present in 39 (6.8%) subjects. Multivariate analysis indicated that ACVS<\/jats:styled-content> is an independent predictor for END<\/jats:styled-content>2 [odds ratio (OR<\/jats:styled-content>) 4.47, 95% confidence interval (CI<\/jats:styled-content>) 1.99\u201310.05) and END<\/jats:styled-content>4 (OR<\/jats:styled-content> 4.24, 95% CI<\/jats:styled-content> 1.94\u20139.23). Furthermore, ACVS<\/jats:styled-content> also correlates with 90\u2010day unfavorable outcome defined as a modified Rankin Scale score >1 point (OR<\/jats:styled-content> 2.93, 95% CI<\/jats:styled-content> 1.15\u20137.48). Both positive and negative predictive values of ACVS<\/jats:styled-content> for END<\/jats:styled-content>2, END<\/jats:styled-content>4 and 90\u2010day prognosis were reasonable and both could be slightly enhanced as long as patients with contralateral artery stenosis or occlusion were excluded.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In patients with MCA<\/jats:styled-content> territory acute ischaemic stroke, especially in those without contralateral internal carotid artery\/MCA<\/jats:styled-content> stenosis or occlusion, ACVS<\/jats:styled-content> might be considered as a neuroimaging predictor for END<\/jats:styled-content> and unfavorable prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12510","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T07:43:44Z","timestamp":1404978224000},"page":"1411-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Asymmetrical cortical vessel sign on susceptibility\u2010weighted imaging: a novel imaging marker for early neurological deterioration and unfavorable prognosis"],"prefix":"10.1111","volume":"21","author":[{"given":"W.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology Jinling Hospital Southern Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurology Jinling Hospital Southern Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Jinling Hospital Southern Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10362"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1400"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.73530"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-012-1029-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6369-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342148"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.12.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000173036.95976.46"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v5.i4.156"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2387-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200008000-00008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-011-0141-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000139370.93203.4A"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.532465"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000091764.61714.79"},{"key":"e_1_2_7_17_1","unstructured":"TsaiFY KaoHW ChanW.Susceptibility\u2010weighted (MR) imaging as prognostic indicator for patient selection with endovascular therapy of acute stroke. 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