{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:19:15Z","timestamp":1776262755719,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hellenic Cooperative Oncology Group research grant","award":["HE R_6OX\/06"],"award-info":[{"award-number":["HE R_6OX\/06"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The oxaliplatin (\u039f\u03a7\u0391)\u2010based regimens <jats:styled-content style=\"fixed-case\">FOLFOX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">XELOX<\/jats:styled-content> can cause peripheral neuropathy. It is unknown if \u039f\u03a7\u0391, alone or in combination regimens, affects the Autonomous Nervous System (<jats:styled-content style=\"fixed-case\">ANS<\/jats:styled-content>). Accordingly, we evaluated the impact of \u039f\u03a7\u0391\u2010based chemotherapy on the <jats:styled-content style=\"fixed-case\">ANS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 36 patients with colorectal cancer, treated with adjuvant m<jats:styled-content style=\"fixed-case\">FOLFOX<\/jats:styled-content>6 or XELOX chemotherapy, and 22 healthy volunteers. For the assessment of ANS function, participants completed a questionnaire and underwent neurophysiological examination at three time points (baseline, 3\u20134\u00a0months and 6\u20138\u00a0months after the first chemotherapy cycle). ANS testing included assessment of the adrenergic cardiovascular function (orthostatic hypotension\u2010OH), parasympathetic heart innervation (ratio 30\/15) and Sympathetic Skin Response (SSR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The values of the 30\/15 ratio were significantly reduced at the two time point assessments compared to baseline (Wilcoxon signed ranks test, both <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), while patients had more often diastolic <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> at the 6\u20138\u00a0month evaluation compared to baseline (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.039). In contrast, <jats:styled-content style=\"fixed-case\">SSR<\/jats:styled-content> was not affected. The incidence of positive responses in the questionnaire assessing the subjective impact of symptoms attributable to <jats:styled-content style=\"fixed-case\">ANS<\/jats:styled-content> dysfunction was higher at the two time points compared to baseline (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.036 and <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oxaliplatin\u2010based chemotherapy is associated with significant effects on the adrenergic cardiovascular reaction and the parasympathetic heart innervation, whereas <jats:styled-content style=\"fixed-case\">SSR<\/jats:styled-content> remains untouched.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12514","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T12:27:31Z","timestamp":1405600051000},"page":"1471-1477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The impact of oxaliplatin\u2010based chemotherapy for colorectal cancer on the autonomous nervous system"],"prefix":"10.1111","volume":"21","author":[{"given":"E. 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