{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:23:57Z","timestamp":1790277837362,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Myasthenia gravis (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>) is an autoimmune disease but certain genetic factors predispose its development. Since susceptibility to different forms of <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> is linked to a number of allelic variants, the aim of this study was to explore the human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) profile of our patients with muscle\u2010specific tyrosine kinase (Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) typing was performed in our cohort of 31 Mu<jats:styled-content style=\"fixed-case\">SK MG<\/jats:styled-content> patients available for the study. The allele groups of <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1* and <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1* loci were typed with sequence\u2010specific oligonucleotide probes and high resolution typing for <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1* was performed using sequence\u2010specific primers. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> frequencies were compared with unrelated healthy bone marrow donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant association of Mu<jats:styled-content style=\"fixed-case\">SK MG<\/jats:styled-content> with alleles <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*14 [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 3.8], <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*16 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.3) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.2) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) was found. In our patients the most frequent <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1* allele was <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05:02. An absolute absence of <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*13 in our cohort of Mu<jats:styled-content style=\"fixed-case\">SK MG<\/jats:styled-content> patients was also found, whilst this allele was present in 25% (495\/1992) of control subjects (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The <jats:styled-content style=\"fixed-case\">HLA DRB<\/jats:styled-content>1*16\u2212<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.9) haplotype was found to be associated with Mu<jats:styled-content style=\"fixed-case\">SK MG<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The strong association of Mu<jats:styled-content style=\"fixed-case\">SK MG<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05 alleles observed in patient series from other countries was confirmed. The novel finding in our cohort of Mu<jats:styled-content style=\"fixed-case\">SK MG<\/jats:styled-content> patients was the absolute absence of <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*13 allele, which might have a protective role in the development of Mu<jats:styled-content style=\"fixed-case\">SK MG<\/jats:styled-content>, at least in our population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12525","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T10:07:01Z","timestamp":1406628421000},"page":"59-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["High frequency of <scp>DQB<\/scp>1*05 and absolute absence of <scp>DRB<\/scp>1*13 in muscle\u2010specific tyrosine kinase positive myasthenia gravis"],"prefix":"10.1111","volume":"22","author":[{"given":"A. V.","family":"Nikolic","sequence":"first","affiliation":[{"name":"Neurology Clinic Department for Neuromuscular Disorders Clinical Center of Serbia Belgrade Serbia"},{"name":"Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. P.","family":"Andric","sequence":"additional","affiliation":[{"name":"Tissue Typing Department Blood Transfusion Institute of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. B.","family":"Simonovic","sequence":"additional","affiliation":[{"name":"Tissue Typing Department Blood Transfusion Institute of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. M.","family":"Rakocevic Stojanovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic Department for Neuromuscular Disorders Clinical Center of Serbia Belgrade Serbia"},{"name":"Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Z.","family":"Basta","sequence":"additional","affiliation":[{"name":"Neurology Clinic Department for Neuromuscular Disorders Clinical Center of Serbia Belgrade Serbia"},{"name":"Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. D.","family":"Bojic","sequence":"additional","affiliation":[{"name":"Medical Faculty Institute for Medical Statistics University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. V.","family":"Lavrnic","sequence":"additional","affiliation":[{"name":"Neurology Clinic Department for Neuromuscular Disorders Clinical Center of Serbia Belgrade Serbia"},{"name":"Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.3.579"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.9.1555"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.027"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.4.382"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114724"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.052415"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.12.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218159.79769.5c"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000339103.08830.86"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.08.271"},{"key":"e_1_2_6_14_1","first-page":"541760","article-title":"Association of HLA\u2010DQB1\u221705:02 and DRB1\u221716 alleles with late\u2010onset, nonthymomatous, AChR\u2010Ab\u2010positive myasthenia gravis","volume":"2012","author":"Testi M","year":"2012","journal-title":"Autoimmune Dis"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312514.66164.88"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12525","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:42:49Z","timestamp":1695508969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,29]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/ene.12525"],"URL":"https:\/\/doi.org\/10.1111\/ene.12525","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,29]]},"assertion":[{"value":"2013-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}