{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T21:54:36Z","timestamp":1781474076849,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Foundation","doi-asserted-by":"crossref","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Patients with myotonic dystrophy type 1 (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1) have an increased incidence of endocrine dysfunction. In this study, the temporal evolution of endocrine dysfunction in patients with<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1 was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endocrine function was assessed in 68 patients with<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1, in whom endocrine function had been followed, on average, for 8\u00a0years. The endocrine function was assessed by measuring the concentration of hormones and metabolites in blood and by validating libido with questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 30 of the 68 patients presented with at least one hormonal dysfunction. When re\u2010evaluated after 8\u00a0years, 57 of 68 patients had endocrine dysfunction. Diabetic patients had increased from one to four. At follow\u2010up, hyperparathyroidism occurred in 25% and abnormal thyroid\u2010stimulating hormone in 21%, compared with 14% and 9% at baseline. Sixteen of 33 men had increased luteinizing hormone levels compared with seven at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings show that endocrine abnormalities amongst patients with<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1 increase over time. Based on these findings it is suggested that correctable endocrine abnormalities should be monitored periodically in this patient group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12542","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T06:53:14Z","timestamp":1408949594000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Endocrine function over time in patients with myotonic dystrophy type 1"],"prefix":"10.1111","volume":"22","author":[{"given":"J. R.","family":"Dahlqvist","sequence":"first","affiliation":[{"name":"Neuromuscular Research Unit Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"\u00d8rngreen","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Witting","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vissing","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0653-2_18"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0371281"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6277-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780199571970.001.0001","volume-title":"Myotonic Dystrophy","author":"Harper PS","year":"2009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.08.037"},{"key":"e_1_2_8_7_1","first-page":"1084","article-title":"Genetic risks for children of women with myotonic dystrophy","volume":"48","author":"Koch MC","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0235"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0710"},{"key":"e_1_2_8_10_1","first-page":"147","article-title":"Use of a standard preparatory diet for the oral glucose tolerance test. Is it necessary?","volume":"36","author":"Harlass FE","year":"1991","journal-title":"J Reprod Med"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278597"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00238-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050155"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2335"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150208"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/107805"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20460"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.3.4624"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02210"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb00889.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8201"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01043.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-5914-3"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12542","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T21:27:55Z","timestamp":1717277275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,25]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/ene.12542"],"URL":"https:\/\/doi.org\/10.1111\/ene.12542","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,25]]},"assertion":[{"value":"2014-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}