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However, most of them have a cross\u2010sectional design or lack a validated definition of a headache\u2010free population at baseline. Therefore, additional population\u2010based studies using a clearly defined headache\u2010free population and a prospective design are warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from two large epidemiological studies, the Nord\u2010Trondelag Health Survey 1995\u20131997 (<jats:styled-content style=\"fixed-case\">HUNT<\/jats:styled-content> 2) and 2006\u20132008 (<jats:styled-content style=\"fixed-case\">HUNT<\/jats:styled-content> 3), were used to evaluate the association between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (systolic, diastolic and pulse pressure) at baseline and headache (migraine and tension type headache) at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An inverse relationship was found between all three <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> measures at baseline in <jats:styled-content style=\"fixed-case\">HUNT<\/jats:styled-content> 2 and any headache in <jats:styled-content style=\"fixed-case\">HUNT<\/jats:styled-content> 3, more evident for systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 0.90 per 10\u00a0mmHg increase in systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.87\u20130.93, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001] and pulse pressure (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a00.84 per 10\u00a0mmHg increase in pulse pressure, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.80\u20130.89, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) than for diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a00.92 per 10\u00a0mmHg increase in diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.87\u20131.00, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.036). The most robust finding, evident for both sexes, was that increased pulse pressure was linked to decreased prevalence of both migraine and tension type headache.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An inverse relationship between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and subsequent development of headache was confirmed in this large\u2010scale population\u2010based cohort study. Nevertheless, further research is needed to investigate the underlying mechanisms explaining these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12547","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T06:53:43Z","timestamp":1408949623000},"page":"156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Blood pressure as a risk factor for headache and migraine: a prospective population\u2010based study"],"prefix":"10.1111","volume":"22","author":[{"given":"C. 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