{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:07:04Z","timestamp":1790230024640,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Several symptoms and signs are characteristic of multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) such as Lhermitte's sign, Uhthoff's phenomenon and painful tonic seizure. Neuromyelitis optica (<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>) is another inflammatory disease of the central nervous system, and most of the opticospinal form of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> is thought to be <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>. This study aimed to investigate the frequencies of symptoms and signs, previously regarded as characteristic of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>, in <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive Japanese <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010plus patients [<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) or partial <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a018)] and <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0128) seen at Chiba University Hospital between 2011 and 2012 were investigated for the frequencies of symptoms and signs characteristic of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Logistic regression analyses were used to identify factors that distinguished <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010plus from <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analyses revealed that tonic seizures, Lhermitte's sign, persistent pain, fatigue and girdle sensation were more frequent in <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010plus patients than in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients. Multivariate logistic regression analysis showed that paroxysmal itching, Uhthoff's phenomenon, Lhermitte's sign and girdle sensation were more characteristic of <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010plus than of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several classical <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> symptoms and signs are more frequent in <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> patients than <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients, which may be caused by the differences in the severity of inflammation, and localization and extensiveness of demyelinated lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12566","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T12:21:41Z","timestamp":1411734101000},"page":"299-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Current symptomatology in multiple sclerosis and neuromyelitis optica"],"prefix":"10.1111","volume":"22","author":[{"given":"M.","family":"Muto","sequence":"first","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sato","sequence":"additional","affiliation":[{"name":"Clinical Research Center Chiba University Hospital Chiba 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