{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:39:17Z","timestamp":1782931157952,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000508, 81322021 and 81271649"],"award-info":[{"award-number":["81000508, 81322021 and 81271649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"crossref","award":["Z121110002512032"],"award-info":[{"award-number":["Z121110002512032"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pearl River Science and Technology Star Fund","award":["2012J2200090"],"award-info":[{"award-number":["2012J2200090"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>This study aimed to reveal the structural basis of post\u2010ischaemic stroke apathy, especially in relation to disruptions in structural connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010eight participants were included. The Apathy Evaluation Scale, clinician version, was used to characterize the severity of apathy. Diffusion tensor imaging tractography was used to examine white matter integrity and to reconstruct white matter networks using 90 nodes based on the automated anatomical labeling atlas. The degree for each node was extracted to determine the relationship to the severity of apathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apathy was not significantly associated with damage to any single brain region. The degrees of 24 nodes (limbic system, three nodes; frontal lobe, six; basal ganglia, two; temporal lobe, three; parietal lobe, three; insula, two; occipital lobe, five) were significantly correlated to the Apathy Evaluation Scale scores. These 24 nodes constituted an apathy\u2010related sub\u2010network and its global and local efficiencies were negatively correlated with apathy levels (global, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.54, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01; local, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.64, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Multivariate logistic regression indicated that decreased global efficiency of this sub\u2010network was an independent risk factor for apathy (odds ratio 0.03, 95% confidence interval 0.01\u20130.04, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007). Efficiencies of the non\u2010apathy\u2010related sub\u2010network (the remaining 66 nodes) did not correlate or predict the presence of apathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010stroke apathy is not due to the dysfunction of a single region or circuit. Rather, it results from disconnection of a complex sub\u2010network of brain regions. This provides new insights into the neuroanatomical basis of post\u2010stroke apathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12575","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T06:50:27Z","timestamp":1413442227000},"page":"341-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Deficiency of brain structural sub\u2010network underlying post\u2010ischaemic stroke apathy"],"prefix":"10.1111","volume":"22","author":[{"given":"S.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Experimental Psychology University of Oxford Oxford UK"},{"name":"Department of Neurology Guangzhou First People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Cadio\u2010vascular surgery Sun Yat\u2010sen Memorial 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