{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:38:51Z","timestamp":1790433531986,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,25]],"date-time":"2014-10-25T00:00:00Z","timestamp":1414195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Municipal Science & Technology Commission","award":["No. D111107003111007"],"award-info":[{"award-number":["No. D111107003111007"]}]},{"DOI":"10.13039\/501100010270","name":"Capital Health research and Development of Special","doi-asserted-by":"crossref","award":["Capital 2011-2004-03"],"award-info":[{"award-number":["Capital 2011-2004-03"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Major Project of China","award":["2011BAI08B02"],"award-info":[{"award-number":["2011BAI08B02"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Background and purpose<\/jats:title>Persons with chronic kidney disease, defined by a reduced estimated glomerular filtration rate and proteinuria, have an increased risk of cardiovascular disease including stroke. However, data from developing countries are limited. Our aim was to assess the relationship between chronic kidney disease and risk of stroke and its subtypes in a community\u2010based population in C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study was based on 92\u00a0013 participants (18\u201398\u00a0years old; 73\u00a0248 men and 18\u00a0765 women) of the K<\/jats:styled-content>ailuan study who at baseline were free from stroke and myocardial infarction and had undergone tests for serum creatinine or proteinuria. Glomerular filtration rate was estimated using the C<\/jats:styled-content>hronic K<\/jats:styled-content>idney D<\/jats:styled-content>isease E<\/jats:styled-content>pidemiology C<\/jats:styled-content>ollaboration formula and proteinuria by the urine dipstick result in laboratory databases. The primary outcome was the first occurrence of stroke. Data were analyzed using C<\/jats:styled-content>ox proportional hazards models adjusted for relevant confounders and results are presented as hazard ratios (HR<\/jats:styled-content>s) with 95% confidence intervals (CI<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Results<\/jats:title>During a follow\u2010up of 4\u00a0years, 1575 stroke events (1128 ischaemic, 406 intracerebral hemorrhagic and 41 subarachnoid hemorrhagic strokes) occurred. After adjustment for variable confounders, patients with proteinuria were found to have increased HR<\/jats:styled-content>s for the total and subtypes of stroke events (HR<\/jats:styled-content> 1.61; 95% CI<\/jats:styled-content> 1.35\u20131.92 for total stroke; HR<\/jats:styled-content> 1.53; 95% CI<\/jats:styled-content> 1.24\u20131.89 for ischaemic stroke; and HR<\/jats:styled-content> 1.90; 95% CI<\/jats:styled-content> 1.35\u20132.67 for hemorrhagic stroke). However, estimated glomerular filtration rate was not associated with incident stroke after adjustment for established cardiovascular risk factors.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Proteinuria increased the risk of stroke in a general C<\/jats:styled-content>hinese population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12580","type":"journal-article","created":{"date-parts":[[2014,10,25]],"date-time":"2014-10-25T07:59:59Z","timestamp":1414223999000},"page":"355-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Impact of proteinuria and glomerular filtration rate on risk of ischaemic and intracerebral hemorrhagic stroke: a result from the K<\/scp>ailuan study"],"prefix":"10.1111","volume":"22","author":[{"given":"Z.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tian Tan Hospital Capital Medical University Beijing 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University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nephrology Beijing Tian Tan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan Hospital Hebei United University Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tian Tan Hospital Capital Medical University Beijing 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