{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:18Z","timestamp":1787836698402,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Action tremor may occur in patients with Parkinson's disease and cause misdiagnosis with other movement disorders such as essential tremor and dystonia. Data on the frequency of action tremor in Parkinson's disease and on the relationships with other motor and non\u2010motor signs are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study of 237 patients with Parkinson's disease staging 1\u20132 on the Hoehn\u2212Yahr scale was conducted. Data on action tremor and other motor and non\u2010motor signs were collected using the Unified Parkinson's Disease Rating Scale part III and the Non\u2010Motor Symptoms Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Action tremor was found in 46% of patients and was associated with both severity of rest tremor (adjusted odds ratio\u00a03.0, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and severity of rigidity (adjusted odds ratio\u00a01.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). No association was found between action tremor and severity of bradykinesia (adjusted odds ratio\u00a00.97, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.4) or axial symptoms (adjusted odds ratio\u00a00.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.3). Moreover, patients who had action tremor reported a significant lower mean number of non\u2010motor symptoms than those who had not (2.1\u00a0\u00b1\u00a01.3 vs. 2.4\u00a0\u00b1\u00a01.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Action tremor is a relatively frequent motor sign in patients with Parkinson's disease staging 1\u20132 on the Hoehn\u2212Yahr scale. Action tremor correlates with rest tremor and rigidity and may be associated with a lower burden of non\u2010motor symptoms. These findings suggest a contribution of non\u2010dopaminergic mechanisms to action tremor pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12583","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T07:46:20Z","timestamp":1415000780000},"page":"223-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Action tremor in Parkinson's disease: frequency and relationship to motor and non\u2010motor signs"],"prefix":"10.1111","volume":"22","author":[{"given":"A. 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