{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:02:02Z","timestamp":1769598122552,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS039422"],"award-info":[{"award-number":["R01 NS039422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>There is mounting evidence that essential tremor (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) is a neurodegenerative disease. Reduced body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) is a clinical feature of many neurodegenerative diseases, yet there has been little documentation of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Essential tremor cases and controls were enrolled in a study of the environmental epidemiology of <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> at Columbia University Medical Center. Weight and height were measured using a standard protocol; <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was weight (kg) divided by height (m<jats:sup>2<\/jats:sup>). Daily calorie count (kcal) was calculated using the Willett Semi\u2010Quantitative Food Frequency Questionnaire. Tremor severity was assessed with a clinical rating scale (total tremor score, range\u00a00\u201336).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 382 <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> cases and 392 controls were similar with respect to age, gender and other demographic variables. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was lower in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> cases than controls [26.7\u00a0\u00b1\u00a05.0 (median\u00a0=\u00a026.2) vs. 27.7\u00a0\u00b1\u00a05.6 (median\u00a0=\u00a026.7), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03] despite the fact that the daily caloric intake was marginally higher in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> cases than controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09). In <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> cases, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was not associated with tremor severity (Spearman's <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.02, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.66) but, among younger onset <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> cases, longer tremor duration was associated with lower <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (Spearman's <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.14, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The observed lower <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> is consistent with the neurodegenerative hypothesis of <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. The data also suggest that some mechanism other than decreased daily caloric intake or an involuntary movement\u2010related increased burning of calories is likely to account for this case\u2212control difference.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12589","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T11:10:09Z","timestamp":1415099409000},"page":"384-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduced body mass index in essential tremor: a study of 382 cases and 392 matched controls"],"prefix":"10.1111","volume":"22","author":[{"given":"E. 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