{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:05:04Z","timestamp":1761807904138,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Background and purpose<\/jats:title>The aim was to investigate the prevalence of restless legs syndrome (RLS<\/jats:styled-content>), fatigue and daytime sleepiness in a large cohort of patients affected by post polio syndrome (PPS<\/jats:styled-content>) and their impact on patient health\u2010related quality of life (HRQoL<\/jats:styled-content>) compared with healthy subjects.<\/jats:p><\/jats:sec>Methods<\/jats:title>PPS patients were evaluated by means of the Stanford Sleepiness Scale and the Fatigue Severity Scale (FSS<\/jats:styled-content>). The Short Form Health Survey (SF\u201036) questionnaire was utilized to assess HRQoL in PPS<\/jats:styled-content>. RLS<\/jats:styled-content> was diagnosed when standard criteria were met. Age and sex matched healthy controls were recruited amongst spouses or friends of PPS subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 66 PPS<\/jats:styled-content> patients and 80 healthy controls were enrolled in the study. A significantly higher prevalence of RLS<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.0005; odds ratio 21.5; 95% confidence interval 8.17\u201357) was found in PPS<\/jats:styled-content> patients (PPS<\/jats:styled-content>\/RLS<\/jats:styled-content>+ 63.6%) than in healthy controls (7.5%). The FSS score was higher in PPS<\/jats:styled-content>\/RLS<\/jats:styled-content>+ than in PPS<\/jats:styled-content>\/RLS<\/jats:styled-content>\u2212 patients (P<\/jats:italic>\u00a0=\u00a00.03). A significant decrease of SF\u201036 scores, including the physical function (P<\/jats:italic>\u00a0=\u00a00.001), physical role (P<\/jats:italic>\u00a0=\u00a00.0001) and bodily pain (P<\/jats:italic>\u00a0=\u00a00.03) domains, was found in PPS<\/jats:styled-content>\/RLS<\/jats:styled-content>+ versus PPS<\/jats:styled-content>\/RLS<\/jats:styled-content>\u2212 patients. Finally, it was found that PPS<\/jats:styled-content>\/RLS<\/jats:styled-content>+ showed a significant correlation between International Restless Legs Scale score and FSS (P<\/jats:italic>\u00a0<\u00a00.0001), as well as between International Restless Legs Scale score and most of the SF\u201036 items (physical role P<\/jats:italic>\u00a0=\u00a00.0018, general health P<\/jats:italic>\u00a0=\u00a00.0009, vitality P<\/jats:italic>\u00a0=\u00a00.0022, social functioning P<\/jats:italic>\u00a0=\u00a00.002, role emotional P<\/jats:italic>\u00a0=\u00a00.0019, and mental health P<\/jats:italic>\u00a0=\u00a00.0003).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings demonstrate a high prevalence of RLS<\/jats:styled-content> in PPS<\/jats:styled-content>, and that RLS<\/jats:styled-content> occurrence may significantly influence the HRQoL and fatigue of PPS<\/jats:styled-content> patients. A hypothetical link between neuroanatomical and inflammatory mechanisms in RLS<\/jats:styled-content> and PPS<\/jats:styled-content> is suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12593","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T11:51:07Z","timestamp":1415879467000},"page":"472-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Restless legs syndrome and post polio syndrome: a case\u2212control study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-2600","authenticated-orcid":false,"given":"A.","family":"Romigi","sequence":"first","affiliation":[{"name":"Neurophysiopathology Unit Sleep Medicine Centre Department of Systems Medicine University of Rome Tor Vergata Rome Italy"},{"name":"IRCCS Neuromed Via Atinense 18, Pozzilli (IS) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pierantozzi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Rome Tor Vergata Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Placidi","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit Sleep Medicine Centre Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit Sleep Medicine Centre Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Albanese","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit Sleep Medicine Centre Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Liguori","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit Sleep Medicine Centre Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nazzaro","sequence":"additional","affiliation":[{"name":"UOC Governo Clinico in Riabilitazione Azienda Ospedaliera S. 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