{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:48:20Z","timestamp":1790797700289,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Sexual dysfunction (SD) is prevalent in multiple sclerosis (MS) patients and affects quality of life. Furthermore, lower urinary tract dysfunction (LUTD) is common in MS patients. Our aim was to determine the relationship between urodynamic findings and SD in a cohort of MS patients with LUTD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2011 to September 2013, 135 consecutive patients with MS in remission phase and LUTD underwent a first urodynamic examination, according to the International Continence Society criteria. Neurological impairment was assessed using the Expanded Disability Status Scale and SD was investigated with the Female Sexual Function Index (FSFI) or the International Index of Erectile Function (IIEF\u201015). Multivariate logistic regression analysis was performed to identify predictors of female SD (FSFI &lt; 26.55) or moderate\u2212severe erectile dysfunction (ED) (IIEF\u2010EF \u2264 16), after adjusting for confounding factors including urodynamic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Subjects with maximum detrusor pressure during involuntary detrusor contraction (PdetmaxIDC) \u226520.0\u00a0cmH\n                      <jats:sub>2<\/jats:sub>\n                      O had lower IIEF\u2010EF, IIEF overall satisfaction (IIEF\u2010OS), FSFI\u2010Arousal, FSFI\u2010Lubrication and FSFI\u2010Orgasm. Subjects with maximum cystometric capacity (MCC) \u2265135 ml had higher IIEF\u2010EF, intercourse satisfaction (IIEF\u2010IS), orgasmic function (IIEF\u2010OF), sexual desire (IIEF\u2010SD), FSFI\u2010Arousal, FSFI\u2010Lubrication, FSFI\u2010Orgasm, FSFI\u2010Satisfaction and FSFI\u2010Pain. On multivariate logistic regression analysis, PdetmaxIDC \u226520\u00a0cmH\n                      <jats:sub>2<\/jats:sub>\n                      O [odds ratio\u00a0(OR) 6.7;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05] and MCC &lt;135\u00a0ml (OR\u00a06.80;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) were predictors of moderate\u2212severe ED. In a model including all previous variables, compliance \u22643\u00a0ml\/cmH\n                      <jats:sub>2<\/jats:sub>\n                      O was an independent predictor of moderate\u2212severe ED (OR 14.49;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). No relationship was found between the previous variables and FSFI &lt;26.55.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Neurogenic bladder is associated with SD in MS patients. The presence of PdetmaxIDC \u226520\u00a0cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, MCC &lt;135\u00a0ml and compliance \u22643\u00a0ml\/cmH\n                      <jats:sub>2<\/jats:sub>\n                      O may significantly predict the presence of moderate\u2212severe ED.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.12595","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T01:57:22Z","timestamp":1416448642000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Relationship between urodynamic findings and sexual function in multiple sclerosis patients with lower urinary tract dysfunction"],"prefix":"10.1111","volume":"22","author":[{"given":"E.","family":"Fragal\u00e0","sequence":"first","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. I.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Di Rosa","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Giardina","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Privitera","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Favilla","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Castelli","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chisari","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Caramma","sequence":"additional","affiliation":[{"name":"Department G.F. 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Ingrassia Section of Neurosciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cimino","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Morgia","sequence":"additional","affiliation":[{"name":"Department of Urology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12397"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02161.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12474"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01314.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02746.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.9.3.341"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200206000-00008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506075651"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23093"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WNF.0000228177.75711.0f"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21097"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22546"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12389"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00238-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278597"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01372.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.08.019"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.20102.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22495"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353274"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068052"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.194"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12635"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12587"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.03.007"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12595","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:31:19Z","timestamp":1696350679000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,19]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/ene.12595"],"URL":"https:\/\/doi.org\/10.1111\/ene.12595","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,19]]},"assertion":[{"value":"2014-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}