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Our study examined asymptomatic polyvascular abnormalities in a general population and with an age of 40+\u00a0years without history of stroke, transient ischaemic attacks and coronary heart disease. <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> was diagnosed by transcranial Doppler sonography and was defined by peak flow velocity criteria; <jats:styled-content style=\"fixed-case\">ECAS<\/jats:styled-content> was diagnosed by carotid duplex sonography and was defined by the diameter of the common carotid artery or internal carotid artery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 4422 study participants, 711 (16.1%) subjects showed an asymptomatic <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> and 292 (6.6%) showed an asymptomatic <jats:styled-content style=\"fixed-case\">ECAS<\/jats:styled-content>. After adjusting for relevant risk factors, higher prevalence of <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> was significantly associated with higher prevalence of pre\u2010hypertension [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a01.55; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.11, 2.16; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010] and hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a01.80; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.53, 2.11; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Stratified by gender, the association was stronger for men than for women. Asymptomatic <jats:styled-content style=\"fixed-case\">ECAS<\/jats:styled-content> was not significantly associated with the prevalence of pre\u2010hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a00.78; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a00.55, 1.10) or of hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a01.06; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a00.91, 1.24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that arterial pre\u2010hypertension in addition to hypertension is associated with a higher prevalence of asymptomatic <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>, more in men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12611","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T12:54:21Z","timestamp":1418734461000},"page":"533-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Arterial pre\u2010hypertension and hypertension in intracranial versus extracranial cerebrovascular stenosis"],"prefix":"10.1111","volume":"22","author":[{"given":"D.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Population Health University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessels Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Gao","sequence":"additional","affiliation":[{"name":"Channing Laboratory Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA"},{"name":"Department of Nutrition Harvard University School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan Hospital Tangshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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