{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:29:45Z","timestamp":1790393385856,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Thirty per cent of amyotrophic lateral sclerosis (ALS) patients have non\u2010motor symptoms, including executive and memory deficits. The <jats:italic>in vivo<\/jats:italic> anatomical basis of memory deficits in ALS has not been elucidated. In this observational study, brain atrophy in relation to memory function was investigated in ALS patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six ALS patients without dementia and 21 healthy volunteers matched for gender, age and education level underwent comprehensive neuropsychological evaluation and T1\u2010 and T2\u2010weighted 3 T magnetic resonance imaging scanning of the brain. Grey and white matter brain volumes were analysed using voxel\u2010based morphometry and age related white matter changes were assessed. The most frequently abnormal memory test (&lt;2 SD below normative data corrected for age, gender and education) was correlated with regional brain volume variations by multiple regression analyses with age, gender and total grey matter volumes as covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immediate and delayed story recall scores were abnormal in 23% of ALS patients and correlated to bilateral hippocampus grey matter volume (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.52 for both memory tests; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05; corrected for age, gender and total grey matter volume). This correlation was not found in healthy controls with similar age, education, anxiety and depression levels and white matter changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prose memory impairment is a frequent finding in this cohort and is associated with hippocampus volume in ALS patients without dementia. These findings complement previous hippocampus changes in imaging studies in ALS and suggest involvement of the hippocampus in cognitive dysfunction of ALS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12615","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T05:36:36Z","timestamp":1419917796000},"page":"547-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Prose memory impairment in amyotrophic lateral sclerosis patients is related to hippocampus volume"],"prefix":"10.1111","volume":"22","author":[{"given":"J.","family":"Raaphorst","sequence":"first","affiliation":[{"name":"Academic Medical Centre Department of Neurology University of Amsterdam Amsterdam The Netherlands"},{"name":"Department of Neurology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"van Tol","sequence":"additional","affiliation":[{"name":"Neuroimaging Centre University Medical Centre Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"de Visser","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Neurology University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"van der Kooi","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Neurology University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Majoie","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Radiology University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. H.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Brain Centre Rudolf Magnus Institute of Neuroscience Department of Neurology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Schmand","sequence":"additional","affiliation":[{"name":"Academic Medical Centre Department of Neurology University of Amsterdam Amsterdam The Netherlands"},{"name":"Department of Psychology University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Veltman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300188"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2011.639376"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318214359f"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824e8f53"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03016.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02801.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.6.1399"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.8.1665"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh170"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482960802645008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00607.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90469-A"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90569-S"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0447-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.5.636"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.9.1571"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20364"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.025"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-6-17"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820510038538"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000167602.38643.29"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr016"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000437313.80913.2c"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.05.035"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.204446"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802654364"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_7_33_1","unstructured":"SPM5.http:\/\/wwwfilionuclacuk\/spm\/2010(accessed 7\/4\/2014)."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.016"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.068"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1007"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.045"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"e_1_2_7_39_1","unstructured":"WFU PickAtlas toolbox.http:\/\/wwwansirwfubmcedu2010(accessed 7\/4\/2014)."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90204-X"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172911.39167.b6"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.5.464"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1990.tb00950.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.02.011"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12096"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-314OC"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.4.482"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12615","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:32:06Z","timestamp":1696365126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,30]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/ene.12615"],"URL":"https:\/\/doi.org\/10.1111\/ene.12615","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,30]]},"assertion":[{"value":"2014-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}