{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:58:11Z","timestamp":1779904691779,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Generalized cerebral ischaemia from cardiovascular dysfunction usually leads to presyncopal dizziness, but several studies reported a higher frequency of rotatory vertigo in cardiovascular patients. Whether generalized cerebral ischaemia due to cardiovascular disorders may produce objective vestibular dysfunction was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three patients with orthostatic dizziness\/vertigo due to profound orthostatic hypotension and 30 controls were recruited. All participants underwent recording of eye movements during two orthostatic challenging tests: the Schellong and the squatting\u2212standing tests. Most patients had neuroimaging, and patients with abnormal eye movements were subjected to follow\u2010up evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptoms associated with orthostatic dizziness\/vertigo included blurred vision, fainting and tinnitus. Ten (30%) of 33 patients developed rotatory vertigo and nystagmus during the Schellong (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) or squatting\u2212standing test (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). Four of them showed pure downbeat nystagmus whilst five had downbeat and horizontal nystagmus with or without torsional component. Patients with orthostatic nystagmus had shorter duration of orthostatic intolerance than those without nystagmus (1.0\u00a0\u00b1\u00a01.6 vs. 11.0\u00a0\u00b1\u00a09.7\u00a0months, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In two patients, orthostatic nystagmus disappeared during follow\u2010up despite the persistence of profound orthostatic hypotension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Generalized cerebral ischaemia caused by orthostatic hypotension induces rotatory vertigo due to objective vestibular dysfunction. The presence of orthostatic vertigo and nystagmus has an association with the duration of orthostatic intolerance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12622","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T14:23:43Z","timestamp":1419949423000},"page":"648-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Vertigo and nystagmus in orthostatic hypotension"],"prefix":"10.1111","volume":"22","author":[{"given":"J.\u2010H.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Neurology Pusan National University School of Medicine Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010D.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"},{"name":"Department of Neurology Bonhospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.\u2010Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. R.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Pusan National University School of Medicine Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010D.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/82.11.1329"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-008-0801-z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0125"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318200d752"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360217"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.1086"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.3.330"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2989-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2011.03.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh532"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.2.207"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.6.1376"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000180405.00560.51"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001219"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6005-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0773-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011747"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110001010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018766"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12622","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:31:33Z","timestamp":1695573093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,30]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ene.12622"],"URL":"https:\/\/doi.org\/10.1111\/ene.12622","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,30]]},"assertion":[{"value":"2014-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}