{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:41:08Z","timestamp":1768909268247,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Recent studies have demonstrated that Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) and subcortical vascular dementia (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD) have white matter (<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>) microstructural changes. However, previous studies on <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease pathologies. Therefore, our aim was to evaluate the divergent topography of <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> microstructural changes in patients with pure <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were clinically diagnosed with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD were prospectively recruited. Forty <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients who were Pittsburgh compound B (PiB) positive [PiB(+) <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>] without <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> hyperintensities and 32 <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients who were PiB negative [PiB(\u2212) <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD] were chosen. Fifty\u2010six cognitively normal individuals were also recruited (<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>). Tract\u2010based spatial statistics of diffuse tensor imaging were used to compare patterns of fractional anisotropy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) and mean diffusivity (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> group, the PiB(+) <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group showed decreased <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> in the bilateral frontal, temporal and parietal WM regions and the genu and splenium of the corpus callosum as well as increased <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> in the left frontal and temporal WM region. PiB(\u2212) <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients showed decreased <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> and increased <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> in all WM regions. Direct comparison between PiB(+) <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and PiB(\u2212) <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD groups showed that the PiB(\u2212) <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD group had decreased <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> across all WM regions and increased <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> in all WM regions except occipital regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that pure <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and pure <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD have divergent topography of <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> microstructural changes including normal appearing <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12645","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T09:33:17Z","timestamp":1421832797000},"page":"709-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["White matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementia"],"prefix":"10.1111","volume":"22","author":[{"given":"Y. 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