{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:34Z","timestamp":1788871894081,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chang Gung Memorial Hospital and National science council","award":["CMRPG8A0511, CMRPG8C041,NSC 100-2314-B-182A-092-MY3, NSC 102-2314-B-182A-059, 98-2314-B-182-034-MY2"],"award-info":[{"award-number":["CMRPG8A0511, CMRPG8C041,NSC 100-2314-B-182A-092-MY3, NSC 102-2314-B-182A-059, 98-2314-B-182-034-MY2"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      Although parkinsonism after carbon monoxide (\n                      <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>\n                      ) intoxication is well known, neurotransmitter deficient networks that are responsible for the severity of parkinsonism have rarely been systemically evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighteen patients with\n                      <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>\n                      \u2010related parkinsonism and nine age\u2010 and sex\u2010matched controls were enrolled for detailed neurological examinations, three\u2010dimensional T1\u2010weighted images, diffusion tensor imaging and\n                      <jats:sup>18<\/jats:sup>\n                      F\u20109\u2010fluoropropyl\u2010(+)\u2010dihydrotetrabenzazine (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      \u2010(+)\u2010\n                      <jats:styled-content style=\"fixed-case\">DTBZ<\/jats:styled-content>\n                      ) positron emission tomography (\n                      <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\n                      ). The structural analysis included voxel\u2010based morphometry to assess grey matter atrophy and tract\u2010based spatial statistics related to white matter involvement. For presynaptic monoaminergic assessment, volume of interest analysis in six subcortical regions and non\u2010parametric voxel\u2010wise comparison were performed on\n                      <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\n                      images with estimation of registration parameters from magnetic resonance images. All the imaging modalities were compared between the patients and controls. For the patients, a regression model for correlation with cognitive behaviour and Unified Parkinson's Disease Rating Scale (\n                      <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>\n                      ) score was used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the patients, monoaminergic deficit networks were found in the caudate, anterior putamen, anterior insular, thalamus and anterior cingulate cortex. The\n                      <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>\n                      revealed significant correlations with the prefrontal white matter fractional anisotropy values and with the\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      \u2010(+)\u2010\n                      <jats:styled-content style=\"fixed-case\">DTBZ<\/jats:styled-content>\n                      uptake values in the caudate nucleus, insular, medial prefrontal and dorsomedial thalamus. The neuropsychiatric inventory score correlated with the\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      \u2010(+)\u2010\n                      <jats:styled-content style=\"fixed-case\">DTBZ<\/jats:styled-content>\n                      uptake values in the anterior cingulate cortex and dorsolateral prefrontal cortex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study demonstrated monoaminergic deficits and white matter damage networks in\n                      <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>\n                      \u2010related parkinsonism that determined the severity of parkinsonism or behaviour changes. As the substantia nigra was spared, the monoaminergic topography of involvement suggests a different pathophysiology in\n                      <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>\n                      \u2010related parkinsonism.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.12672","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T04:19:13Z","timestamp":1424233153000},"page":"845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<sup>18<\/sup>\n                    F\u2010\n                    <scp>FP<\/scp>\n                    \u2010(+)\u2010\n                    <scp>DTBZ<\/scp>\n                    positron emission tomography detection of monoaminergic deficient network in patients with carbon monoxide related parkinsonism"],"prefix":"10.1111","volume":"22","author":[{"given":"C.\u2010C.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Neurology Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.\u2010T.","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Healthy Aging Research Centre and Department of Medical Imaging and Radiological Sciences Chang Gung University Taoyuan Taiwan"},{"name":"Department of Nuclear Medicine and Centre for Advanced Molecular Imaging and Translation Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung 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