{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:47:17Z","timestamp":1772858837475,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Neurosyphilis is a neurological disease that involves infection of the central nervous system with <jats:italic>Treponema pallidum<\/jats:italic>. With increases in unsafe sexual behaviour, syphilis has re\u2010emerged worldwide. To explore the amyloid and tau metabolism in neurosyphilis patients in different stages, the levels of Alzheimer\u2010type biomarkers in general paresis (<jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>) and asymptomatic neurosyphilis (<jats:styled-content style=\"fixed-case\">ANS<\/jats:styled-content>) patients in comparison to patients with Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) and normal controls (<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s) were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>\u03b2\u2010amyloid peptide 1\u201042 (A\u03b242) and A\u03b2 1\u201040 (A\u03b240), tau hyperphosphorylated at threonine 181 (p\u2010tau181) and total tau (t\u2010tau) in cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) were measured by enzyme\u2010linked immunosorbent assay kits in 44 patients with GP, 10 patients with ANS, 45 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and 39 NCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alzheimer's disease patients had lower <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> A\u03b242 levels combined with higher <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> t\u2010tau and p\u2010tau181 levels than other groups (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). The <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> A\u03b242 levels decreased in GP compared to <jats:styled-content style=\"fixed-case\">ANS<\/jats:styled-content> and NCs (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> A\u03b240, t\u2010tau and p\u2010tau181 levels were not different between the GP, ANS or <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our research has demonstrated that GP, ANS and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients are characterized by distinct patterns of the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> biomarkers A\u03b2 and tau. The distinct <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> A\u03b2 pattern in GP suggests the existence of abnormal A\u03b2 metabolism. Furthermore, different levels of <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> A\u03b2 will be helpful for the differentiation between different stages of neurosyphilis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12680","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T05:13:13Z","timestamp":1424754793000},"page":"853-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Different cerebrospinal fluid levels of <scp>A<\/scp>lzheimer\u2010type biomarker A\u03b242 between general paresis and asymptomatic neurosyphilis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-5530","authenticated-orcid":false,"given":"X.","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Neurology Guangzhou Brain Hospital Affiliated Hospital of Guangzhou Medical University Guangzhou 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