{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:20:26Z","timestamp":1786443626859,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 12\/00772"],"award-info":[{"award-number":["PI 12\/00772"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 13\/937"],"award-info":[{"award-number":["PI 13\/937"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Myasthenia gravis (MG) may become life\u2010threatening if patients have respiratory insufficiency or dysphagia. This study aimed to determine the incidence, demographic characteristics, risk factors, response to treatment and outcome of these life\u2010threatening events (LTEs) in a recent, population\u2010based sample of MG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of MG patients who presented with an LTE between 2000 and 2013 was performed. Participants were identified from a neuromuscular diseases registry in Spain that includes 648 patients with MG (NMD\u2010ES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two (9.56%) patients had an LTE. Thirty\u2010two were classified as class V according to the MG Foundation of America, and 30 as class IVB. Fifty per cent were previously diagnosed with MG and median duration of the disease before the LTE was 24\u00a0months (3\u2013406). The most common related factor was infection (<jats:italic>n<\/jats:italic>\u00a0=\u00a018). All patients received intravenous human immunoglobulin; 11 had a second infusion and six had plasma exchange. Median time to feeding tube removal was 13\u00a0days (1\u2013434). Median time to weaning from ventilation was 12\u00a0days (3\u2013176), and it was significantly shorter in late onset MG (\u226550\u00a0years) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019). LTEs improved &lt;2\u00a0weeks in 55.8% but did not improve until after 1\u00a0month in 20% of patients. Four patients died. No other factors influenced mortality or duration of LTEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The percentage of LTEs in MG patients was low, particularly amongst those previously diagnosed and treated for the disease. The significant percentage of treatment\u2010resistant LTEs indicates that more effective treatment approaches are needed for this vulnerable sub\u2010population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12703","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T13:58:03Z","timestamp":1428328683000},"page":"1056-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Myasthenia gravis: descriptive analysis of life\u2010threatening events in a recent nationwide registry"],"prefix":"10.1111","volume":"22","author":[{"given":"A.","family":"Ramos\u2010Fransi","sequence":"first","affiliation":[{"name":"Neuromuscular Disorders Unit Neurology Department Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rojas\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Neuromuscular Disorders Unit Neurology Department Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Medicine Department Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Segovia","sequence":"additional","affiliation":[{"name":"Neuromuscular Disorders Unit Neurology Department Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"M\u00e1rquez\u2010Infante","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology Hospital Universitario Virgen del Roc\u00edo Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Cl\u00ednico de Santiago Santiago Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Coll\u2010Cant\u00ed","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitari Germans Trias i Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Jeric\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology Complejo Hospitalario de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Illa","sequence":"additional","affiliation":[{"name":"Neuromuscular Disorders Unit Neurology Department Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Medicine Department Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Myasthenia NMD\u2010ES Study 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