{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:53:35Z","timestamp":1787788415859,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The inferior cerebellar peduncle (<jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>) contains various fibres to and from the cerebellum relating to the integration of the proprioceptive and vestibular functions. However, the full clinical features of isolated unilateral <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> lesions have not been defined in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight consecutive patients with isolated unilateral <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> lesions at the pontine level (six with stroke, one with multiple sclerosis and one with brainstem encephalitis) received bedside neurological and neuro\u2010otological evaluations and underwent laboratory tests including measurements of the subjective visual vertical (<jats:styled-content style=\"fixed-case\">SVV<\/jats:styled-content>) and ocular torsion, bithermal caloric tests and pure tone audiometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients developed isolated acute vestibular syndrome (<jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content>) with ipsilesional spontaneous nystagmus (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and contralesional ocular tilt reaction (<jats:styled-content style=\"fixed-case\">OTR<\/jats:styled-content>) and\/or <jats:styled-content style=\"fixed-case\">SVV<\/jats:styled-content> tilt (<jats:italic>n<\/jats:italic>\u00a0=\u00a07). In view of the normal head impulse test in all patients and skew deviation in one, our patients met the criteria for <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content> from central lesions. Five patients showed a directional dissociation between the <jats:styled-content style=\"fixed-case\">OTR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SVV<\/jats:styled-content> tilt and body lateropulsion that fell to the lesion side whilst the <jats:styled-content style=\"fixed-case\">OTR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SVV<\/jats:styled-content>tilt was contraversive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A unilateral <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> lesion at the pontine level leads to the development of isolated <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content>. However, a negative head impulse test and directional dissociation between <jats:styled-content style=\"fixed-case\">OTR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SVV<\/jats:styled-content> tilt and body lateropulsion may distinguish lesions involving unilateral <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> at the pontine level from those affecting other vestibular structures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12705","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T06:32:12Z","timestamp":1428301932000},"page":"1062-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Inferior cerebellar peduncular lesion causes a distinct vestibular syndrome"],"prefix":"10.1111","volume":"22","author":[{"given":"J.\u2010H.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Neurology Pusan National University School of Medicine Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010D.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Bonhospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. R.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science Kyungdong University Goseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute and Department of Neurology Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010D.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital Pusan National University School of Medicine and Biomedical Research Institute Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Neuroanatomy Through Clinical Cases","author":"Blumenfeld H","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/58.2.174"},{"key":"e_1_2_7_4_1","volume-title":"Neuroanatomy: Text and Atlas","author":"Martin JH","year":"1996"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.527762"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260224.60943.c2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1472-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100174"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.551234"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360304"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310409"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.106237"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000280459.05326.af"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350406"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.03.022"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr269"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238500.02302.b4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn086"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404263517"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.11.060"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.06.014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152040.27264.1A"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7139-0"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12705","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:29:26Z","timestamp":1695515366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/ene.12705"],"URL":"https:\/\/doi.org\/10.1111\/ene.12705","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,6]]},"assertion":[{"value":"2014-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}