{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:08:37Z","timestamp":1790737717697,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"\n Background and purpose<\/jats:title>\n \n The recently developed composite autonomic symptom score 31 (\n COMPASS<\/jats:styled-content>\n \u201031) is a questionnaire that assess symptoms of dysautonomia. It was distilled from the well\u2010established Autonomic Symptom Profile questionnaire.\n COMPASS<\/jats:styled-content>\n \u201031 has not yet been externally validated. To do so, its psychometric properties and convergent validity in patients with and without objective diagnosis of small fiber polyneuropathy (\n SFPN<\/jats:styled-content>\n ) were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Internal validity and reliability of\n COMPASS<\/jats:styled-content>\n \u201031 were assessed in participants with or without\n SFPN<\/jats:styled-content>\n spanning the full range of severity of autonomic symptoms. Convergent validity was assessed by comparing results of the\n COMPASS<\/jats:styled-content>\n \u201031 with the \u201cgold standard\u201d autonomic function testing that measures cardiovagal, adrenergic and sudomotor functions. Additionally, relationships between\n COMPASS<\/jats:styled-content>\n \u201031 and the Short Form McGill Pain Questionnaire, Short Form Health Survey and 0\u201310 numeric pain scale were measured.\n COMPASS<\/jats:styled-content>\n \u201031 and all other questionnaire results were compared between patients with or without evidence of\n SFPN<\/jats:styled-content>\n , objectively confirmed by distal\u2010leg\n PGP<\/jats:styled-content>\n 9.5\u2010immunolabeled skin biopsy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Amongst 66 participants (28\n SFPN<\/jats:styled-content>\n +, 38\n SFPN<\/jats:styled-content>\n \u2212),\n COMPASS<\/jats:styled-content>\n \u201031 total scores had excellent internal validity (Cronbach's\n \u03b1<\/jats:italic>\n \u00a0=\u00a00.919), test\u2013retest reliability (\n r<\/jats:italic>\n s<\/jats:sub>\n \u00a0=\u00a00.886;\n P<\/jats:italic>\n \u00a0<\u00a00.001) and good convergent validity (\n r<\/jats:italic>\n s<\/jats:sub>\n \u00a0=\u00a00.474;\n P<\/jats:italic>\n \u00a0<\u00a00.001).\n COMPASS<\/jats:styled-content>\n \u201031 scores differed between subjects with or without\n SFPN<\/jats:styled-content>\n (\n Z<\/jats:italic>\n \u00a0=\u00a0\u22123.296,\n P<\/jats:italic>\n \u00a0<\u00a00.001) and demonstrated fair diagnostic accuracy. Area under the Receiver Operating Characteristic curve was 0.749 (\n P<\/jats:italic>\n \u00a0=\u00a00.01, 95% confidence interval 0.627\u20130.871).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n COMPASS<\/jats:styled-content>\n \u201031 has good psychometric properties in the population of patients being evaluated for\n SFPN<\/jats:styled-content>\n and thus it might be useful as an initial screening tool for the more expensive\n SFPN<\/jats:styled-content>\n objective tests.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.12717","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T03:57:24Z","timestamp":1429761444000},"page":"1124-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Validation of the composite autonomic symptom scale 31 (\n COMPASS<\/scp>\n \u201031) in patients with and without small fiber polyneuropathy"],"prefix":"10.1111","volume":"22","author":[{"given":"R.","family":"Treister","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"O'Neil","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Downs","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Oaklander","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston MA USA"},{"name":"Department of Pathology (Neuropathology) Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2012.00387.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60631-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.3.523"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.10.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10181"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03023.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2008.11.011"},{"key":"e_1_2_7_9_1","volume-title":"Encyclopedia of Biostatistics","author":"Vet HCW","year":"1998"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bc01a4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_7_16_1","first-page":"S68","article-title":"Normal innervation in distal\u2010leg skin biopsies: evidence of superabundance in youth, subsequent axonal pruning, plus new diagnostic recommendations","volume":"68","author":"Klein MM","year":"2010","journal-title":"Ann Neurol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2013.9.1.1"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12717","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:29:38Z","timestamp":1695500978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/ene.12717"],"URL":"https:\/\/doi.org\/10.1111\/ene.12717","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]},"assertion":[{"value":"2014-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}