{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:00:17Z","timestamp":1789596017109,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Depressed mood is a common psychiatric problem associated with Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), and studies have suggested a benefit of rasagiline treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ACCORDO<\/jats:styled-content> (see the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#ene12724-app-0001\"\/>) was a 12\u2010week, double\u2010blind, placebo\u2010controlled trial to evaluate the effects of rasagiline 1\u00a0mg\/day on depressive symptoms and cognition in non\u2010demented <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients with depressive symptoms. The primary efficacy variable was the change from baseline to week 12 in depressive symptoms measured by the Beck Depression Inventory (<jats:styled-content style=\"fixed-case\">BDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) total score. Secondary outcomes included change from baseline to week 12 in cognitive function as assessed by a comprehensive neuropsychological battery; Parkinson's disease quality of life questionnaire (<jats:styled-content style=\"fixed-case\">PDQ<\/jats:styled-content>\u201039) scores; Apathy Scale scores; and Unified Parkinson's Disease Rating Scale (<jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>) subscores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and twenty\u2010three patients were randomized. At week 12 there was no significant difference between groups for the reduction in total <jats:styled-content style=\"fixed-case\">BDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> score (primary efficacy variable). However, analysis at week 4 did show a significant difference in favour of rasagiline (marginal means difference\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>: rasagiline \u22125.46\u00a0\u00b1\u00a00.73 vs. placebo \u22123.22\u00a0\u00b1\u00a00.67; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). There were no significant differences between groups on any cognitive test. Rasagiline significantly improved <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content> Parts I (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) scores versus placebo at week 12. <jats:italic>Post hoc<\/jats:italic> analyses showed the statistical superiority of rasagiline versus placebo in the <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content> Part I depression item (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) and <jats:styled-content style=\"fixed-case\">PDQ<\/jats:styled-content>\u201039 mobility (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and cognition domains (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with rasagiline did not have significant effects versus placebo on depressive symptoms or cognition in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients with moderate depressive symptoms. Although limited by lack of correction for multiple comparisons, <jats:italic>post hoc<\/jats:italic> analyses signalled some improvement in patient\u2010rated cognitive and depression outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12724","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T06:53:56Z","timestamp":1431413636000},"page":"1184-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["A randomized clinical trial to evaluate the effects of rasagiline on depressive symptoms in non\u2010demented Parkinson's disease patients"],"prefix":"10.1111","volume":"22","author":[{"given":"P.","family":"Barone","sequence":"first","affiliation":[{"name":"University of Salerno Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Second University of Naples Caserta 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