{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:59:21Z","timestamp":1775077161558,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The stroke severity on admission and clinical outcomes were compared between ischaemic stroke patients with non\u2010valvular atrial fibrillation (<jats:styled-content style=\"fixed-case\">NVAF<\/jats:styled-content>) of the persistent (Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) and paroxysmal (<jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>) types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised 9293 patients with cardioembolic stroke and <jats:styled-content style=\"fixed-case\">NVAF<\/jats:styled-content> who were registered in the Japanese stroke databank: 6522 had Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> (70.2%) and 2771 had <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> (29.8%). Stroke severity on admission and the clinical outcomes on discharge were retrospectively compared between these patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The National Institutes of Health Stroke Scale score on admission (median, interquartile range) was 10 (3\u201320) for Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients and 7 (2\u201317) for <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> patients, indicating that stroke severity on admission was significantly worse in Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients than <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Good outcomes (modified Rankin scale score \u22642) were achieved by 45% Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients and 53% <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> patients. Thus, Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients had significantly poorer clinical outcomes than <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In\u2010hospital mortality was significantly higher amongst Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients (11%) than <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> patients (8%) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Multivariate analysis of factors contributing to clinical outcomes showed that Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> was a contributing factor for in\u2010hospital mortality (odds ratio 1.261; 95% confidence interval 1.011\u20131.652; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Amongst cardioembolic stroke patients with <jats:styled-content style=\"fixed-case\">NVAF<\/jats:styled-content>, those with Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> have significantly higher stroke severity on admission than those with <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>, and Pe<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> is a factor contributing to in\u2010hospital mortality. Thus, our study suggests that the type of atrial fibrillation affects stroke severity and clinical outcomes following cerebral infarction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12728","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T06:52:59Z","timestamp":1431413579000},"page":"1215-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Features of cardioembolic stroke with persistent and paroxysmal atrial fibrillation \u2013 a study with the Japan Stroke Registry"],"prefix":"10.1111","volume":"22","author":[{"given":"I.","family":"Deguchi","sequence":"first","affiliation":[{"name":"Department of Neurology Saitama Medical University International Medical Center Hidaka Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Saitama Medical University International Medical Center Hidaka Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Department of Neurology Saitama Medical University International Medical Center Hidaka Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Chief Investigator of Japan Standard Stroke Registry Study Group Shimane University Matsue Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Tanahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Saitama Medical University International Medical Center Hidaka Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Japan Standard Stroke Registry Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.076"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn599"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(99)00214-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1001.097093"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.048827"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.676551"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2006.08.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.68.568"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.040"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12728","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:33:29Z","timestamp":1695512009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/ene.12728"],"URL":"https:\/\/doi.org\/10.1111\/ene.12728","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]},"assertion":[{"value":"2014-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}