{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:21:17Z","timestamp":1791829277922,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Information about metabolic comorbidities in patients with multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) is scarce. Our aim was to examine the prevalence of the metabolic syndrome (MetS) and its components in patients with long duration of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and significant disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic and clinical data, weight, height, waist circumference, blood pressure, and levels of fasting glucose, triglycerides and high density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C) were obtained from 130 <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients with Extended Disability Status Scale (<jats:styled-content style=\"fixed-case\">EDSS<\/jats:styled-content>) score \u22653.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010two percent were female, mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> age 55.8\u00a0\u00b1\u00a06.0, range 45\u201365\u00a0years, disease duration 18.2\u00a0\u00b1\u00a010.1\u00a0years, <jats:styled-content style=\"fixed-case\">EDSS<\/jats:styled-content> 5.5\u00a0\u00b1\u00a01.0. Obesity [body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>)\u00a0\u2265\u00a030\u00a0kg\/m<jats:sup>2<\/jats:sup>] was present in 18.5% and overweight (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 25.0\u201329.9\u00a0kg\/m<jats:sup>2<\/jats:sup>) in 34.6%. The prevalence of the MetS was 30% with no gender difference. Fifty\u2010six percent had central obesity by waist circumference, 28% treated hypertension, 45.8% elevated blood pressure, 11% type 2 diabetes mellitus, 31.4% treated dyslipidemia, 28.8% elevated triglyceride levels and 31.4% had low <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C. <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients with MetS were significantly older (59.0\u00a0\u00b1\u00a05.5 vs. 53.8\u00a0\u00b1\u00a05.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and heavier (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 29.0\u00a0\u00b1\u00a06.9 vs. 25.1\u00a0\u00b1\u00a04.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0009). There were no differences between the groups in neurological disability by the <jats:styled-content style=\"fixed-case\">EDSS<\/jats:styled-content> (5.7\u00a0\u00b1\u00a01.0 vs. 5.4\u00a0\u00b1\u00a01.0), disease duration (18.4\u00a0\u00b1\u00a09.9 vs. 18.2\u00a0\u00b1\u00a010.2\u00a0years) and number of steroid courses received (6.6\u00a0\u00b1\u00a09.5 vs. 6.3\u00a0\u00b1\u00a08.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to the general population, adult disabled <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients had lower rates of obesity and overweight, as assessed by <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. Despite these reduced rates, the prevalence of the MetS was similar to the general population. Specifically higher rates of increased waist circumference were found, suggesting that the lower <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> may be misleading in terms of health risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12738","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T07:51:21Z","timestamp":1431589881000},"page":"1275-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Prevalence of overweight, obesity and metabolic syndrome components in multiple sclerosis patients with significant disability"],"prefix":"10.1111","volume":"22","author":[{"given":"O.","family":"Pinhas\u2010Hamiel","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology and Diabetes Unit Edmond and Lily Safra Children's Hospital Sheba Medical Center Ramat\u2010Gan Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Livne","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Multiple Sclerosis Center Sheba Medical Center Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Harari","sequence":"additional","affiliation":[{"name":"Medistat Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Achiron","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Multiple Sclerosis Center Sheba Medical Center Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62037-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.064"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513504252"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(03)00466-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/981070"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e318194f8b5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0781-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_7_10_1","first-page":"219","article-title":"Overweight and obesity prevalence in Israel: findings of the first national health and nutrition survey (MABAT)","volume":"7","author":"Keinan\u2010Boker L","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0446"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.365"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dhjo.2012.03.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20615"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890802004959"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03668.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514533162"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.034"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2008.06.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0186"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12738","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:23:42Z","timestamp":1695507822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/ene.12738"],"URL":"https:\/\/doi.org\/10.1111\/ene.12738","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,14]]},"assertion":[{"value":"2015-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}