{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:18:19Z","timestamp":1775337499659,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kuopio University Hospital"},{"name":"VTR Fund"},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Factors affecting health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) were explored in patients with idiopathic normal pressure hydrocephalus (<jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the 15D instrument <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL was evaluated in 132 patients diagnosed with <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> by clinical and neuroradiological examinations. The severity of <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> symptoms was measured with the <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> grading scale (<jats:styled-content style=\"fixed-case\">iNPHGS<\/jats:styled-content>), depressive symptoms with the Beck Depression Inventory (<jats:styled-content style=\"fixed-case\">BDI<\/jats:styled-content>\u201021) and cognitive impairment with the Mini\u2010Mental State Examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 15D score (on a 0\u20131 scale) of patients with <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> was significantly lower than that of an age\u2010 and gender\u2010matched sample of the general population [0.718 (0.103) vs. 0.870 (0.106); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]. The mean 15D score was lower in <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> patients with moderate or severe depressive symptoms than in patients without depressive symptoms (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). According to stepwise multiple linear regression analysis, a higher total <jats:styled-content style=\"fixed-case\">iNPHGS<\/jats:styled-content> score (<jats:italic>b<\/jats:italic>\u00a0=\u00a0\u22120.62, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and a higher <jats:styled-content style=\"fixed-case\">BDI<\/jats:styled-content>\u201021 total score (\u03b2\u00a0=\u00a0\u22120.201, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) predicted a lower 15D score; in combination, these explained 51% of the variance in the 15D score (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.506, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Idiopathic normal pressure hydrocephalus impairs patients\u2019 <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL on multiple dimensions, similarly to other chronic diseases. Potentially treatable depressive symptoms contribute greatly to the <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL impairment of <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> patients, but only if they are moderate or severe. The 15D portrayed <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL dimensions affected by <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> in a similar way to broader assessment batteries and thus is a potentially useful tool for treatment evaluation and cost\u2212utility analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12755","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T06:44:37Z","timestamp":1435128277000},"page":"1391-1399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Health\u2010related quality of life in patients with idiopathic normal pressure hydrocephalus"],"prefix":"10.1111","volume":"22","author":[{"given":"A.","family":"Junkkari","sequence":"first","affiliation":[{"name":"Neurosurgery of NeuroCenter Kuopio University Hospital University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sintonen","sequence":"additional","affiliation":[{"name":"Hjelt Institute\/Department of Public Health University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Nerg","sequence":"additional","affiliation":[{"name":"Neurology Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"},{"name":"Neurology of NeuroCenter Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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