{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:06:15Z","timestamp":1790129175153,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Parkinson Foundation"},{"DOI":"10.13039\/100008443","name":"Swedish Parkinson's Disease Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008443","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008084","name":"Swedish Association of Persons with Neurological Disabilities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008084","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brain Foundation"},{"name":"Foundation of Loo and Hans \u00d6sterman"},{"name":"University of Ume\u00e5"},{"name":"Foundation for Clinical Neuroscience at Ume\u00e5 University Hospital"},{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten County Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"crossref"}]},{"name":"King Gustaf V's and Queen Victoria's Freemason Foundation"},{"name":"Foundation of Max and Edit Follin"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      This study employs magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) diffusion tensor imaging to compare diffusion measures in the brains of patients with Parkinson's disease (\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      ) with healthy controls using longitudinal data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One\u2010hundred and twenty\u2010two patients and 34 controls were included at baseline. The\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      investigations were repeated after 1, 3 and 5\u00a0years. The diffusion measures were quantified using fractional anisotropy and mean, radial and axial diffusion (\n                      <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ). Regions of interest included the anterior, middle and posterior substantia nigra (\n                      <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>\n                      ), but also other areas. Linear models were used to test for the effect of disease and hemispheric lateralization. The\n                      <jats:italic>P<\/jats:italic>\n                      value was set at 0.05 (Bonferroni corrected).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fractional anisotropy and\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      were increased in the three nigral subareas in\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), but\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>\n                      were unaltered. The right\n                      <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>\n                      had higher\n                      <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\n                      than the left in all subareas (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      were increased in the right anterior part (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.04), whereas\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>\n                      were decreased in the right middle and posterior parts (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The left middle cerebellar peduncle had increased\n                      <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and decreased\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) compared to the right. Diffusion measures did not progress over time and side differences were not related to disease or lateralization of symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased FA in the SN in PD indicates gliosis and inflammation in the nuclei, but possibly also intrusion of surrounding fibres into the shrinking structure. The hemispheric side differences of diffusion might reflect natural lateralization of connectivity, but their relation to PD must be studied further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.12760","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T03:13:03Z","timestamp":1435547583000},"page":"1408-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Fractional anisotropy in the substantia nigra in Parkinson's disease: a complex picture"],"prefix":"10.1111","volume":"22","author":[{"given":"N.","family":"Lenfeldt","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Neuroscience Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Radiation Sciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nyberg","sequence":"additional","affiliation":[{"name":"Department of Radiation Sciences Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Department of Integrative Medical Biology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Birgander","sequence":"additional","affiliation":[{"name":"Department of Radiation Sciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Forsgren","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Neuroscience Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000340982.01727.6e"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318284070c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.10.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102277"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7080-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq212"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23643"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.021873"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23917"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25182"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25491"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.086"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.07.032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.10.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.05.021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.06.050"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.09.017"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.02.010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07639.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1381"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"Validation of reduced fractional anisotropy measures in the substantia nigra of Parkinson patients using DAT imaging","volume":"19","author":"Harper L","year":"2011","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000398"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130242"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.12.JNS131537"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.055"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.012"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12760","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:24:41Z","timestamp":1695536681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,29]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/ene.12760"],"URL":"https:\/\/doi.org\/10.1111\/ene.12760","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,29]]},"assertion":[{"value":"2014-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}